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Inhibition of the Endogenous GIP Response With a GIP Receptor Antagonist — GA-3  

Glucose Metabolism Disorders Clinical Trial

Official title:
Inhibition of the Endogenous GIP Response With a GIP Receptor Antagonist (GA-3)

Clinical Trial Summary

Delinieation of GIP's effects during an oral glucose tolerance test (OGTT) in humans using GIP receptor antagonisation.

Clinical Trial Description

Aim: To evaluate the role of GIPR signalling in postprandial physiology, including bone and glucose homeostasis, using a naturally occurring GIP fragment (GIP-A), which antagonises the GIPR.

Eighteen healthy men (age 18-70 years, BMI 19-35 kg/m2) with normal kidney and liver parameters and haemoglobin levels and no first-degree relatives with type 2 diabetes will be included in a randomised, double-blinded, placebo-controlled cross-over study. Study consists of four study days with concomitant infusions of A) GIP-A, B) GLP-1 receptor antagonist Exendin[9-39], C) GIP-A + Exendin[9-39], or D) saline (placebo). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03133741
Study type Interventional
Source University Hospital, Gentofte, Copenhagen
Contact
Status Completed
Phase N/A
Start date March 1, 2017
Completion date July 1, 2017
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