Metabolic Consequences of Heterozygous Hereditary Fructose Intolerance

Glucose Metabolism Disorders Clinical Trial

Official title: Are Heterozygous Carriers for Hereditary Fructose Intolerance Predisposed to Metabolic Disturbances When Exposed to Fructose?

Status Completed

Clinical Trial Summary

Background: High fructose intake increases blood lactate, triglyceride and uric acid concentrations. Uric acid may contribute to insulin resistance and dyslipidemia in the general population. In patients with hereditary fructose intolerance fructose consumption is associated with acute hypoglycemia, renal tubular acidosis, and hyperuricemia.

Objective: We investigated whether asymptomatic carriers for hereditary fructose intolerance (HFI) would have a higher sensitivity to adverse effects of fructose than the general population.

Design: Eight subjects heterozygous for HFI (hHFI; 4 males, 4 females) and eight controls received for 7 days a low fructose diet and on the eighth day ingested a test meal calculated to provide 25% of basal energy requirement containing labeled fructose (13C fructose 0.35 g/kg), protein (0.21 g/kg) and lipid (0.22 g/kg). Total fructose oxidation, total endogenous glucose production (by 6,6-2H2-glucose dilution), carbohydrate and lipid oxidation, lipids, uric acid, lactate, creatinine, urea and amino acids were monitored for 6 hours.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Fructose Intolerance
• Fructose Metabolism, Inborn Errors
• Glucose Metabolism Disorders
• Hereditary Fructose Intolerance
• Metabolic Diseases
• Metabolism, Inborn Errors

• NCT number: NCT02979106
• Study type: Interventional
• Source: University of Lausanne
• Status: Completed
• Phase: N/A
• Start date: January 2015
• Completion date: November 2016