Glucose Intolerance Clinical Trial
— GLYCEMIAOfficial title:
Control of Postprandial Glycemia: the Roles of Diet and Exercise
Verified date | April 2019 |
Source | University of Michigan |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Specific aims of the study are:
1. to evaluate whether a 24-h exposure to a 25%-carbohydrate diet will reduce postprandial
glycemia to the same extent in the evening (19 h) as in the morning (7 h),. and
2. to determine whether one hour of post-meal moderate intensity exercise (at 50% of
maximal effort) will further reduce postprandial glycemia.
The outcome measures are: plasma concentrations of glucose, insulin,
glucose-dependent-insulinotropic peptide (GIP), leptin, and the ketone body
beta-hydroxybutyrate.
Status | Completed |
Enrollment | 8 |
Est. completion date | April 2019 |
Est. primary completion date | August 31, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 50 Years to 65 Years |
Eligibility |
Inclusion Criteria: - postmenopausal - normal blood glucose - no cholesterol medication - age between 50 an 65 years - overweight but not obese - BMI between 25 and 30 kg/m2 - weight-stable during past 6 months - exercise less than 20 minutes three times a week Exclusion Criteria: - metabolic disease other than hormonally-corrected hypothyroidism - musculo-skeletal disability that would preclude exercise - smoker - do not meet inclusion criteria |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University of Michigan | Northern Michigan University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Postprandial glucose concentration | The area under the postprandial glucose curve | Four hours: 19:20 to 23:20 in the evening trials; 7:20 to 11:20 in the morning trials | |
Primary | Postprandial insulin concentration | The area under the postprandial insulin curve | Four hours: 19:20 to 23:20 in the evening trials; 7:20 to 11:20 in the morning trials | |
Secondary | Postprandial glucose-dependent insulinotropic peptide (GIP) concentration | The area under the postprandial GIP curve | Four hours: 19:20 to 23:20 in the evening trials; 7:20 to 11:20 in the morning trials | |
Secondary | Postprandial beta-hydroxybutyrate concentration | The area under the beta-hydroxybutyrate postprandial curve | Four hours: 19:20 to 23:20 in the evening trials; 7:20 to 11:20 in the morning trials | |
Secondary | Postprandial leptin concentration | The area under the leptin postprandial curve | Four hours: 19:20 to 23:20 in the evening trials; 7:20 to 11:20 in the morning trials |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05544266 -
Rare and Atypical Diabetes Network
|
||
Completed |
NCT03241121 -
Study of Eating Patterns With a Smartphone App and the Effects of Time Restricted Feeding in the Metabolic Syndrome
|
N/A | |
Completed |
NCT03809182 -
Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels.
|
Phase 4 | |
Completed |
NCT03675360 -
Low-Carbohydrate Dietary Pattern on Glycemic Outcomes Trial
|
N/A | |
Not yet recruiting |
NCT01402362 -
Prevalence of Glucose Intolerance and Risk Factors in Ethiopian Immigrants in Israel; Follow-up Study.
|
N/A | |
Completed |
NCT01671293 -
Multicomponent Telecare Model for Supporting Prediabetes Patients
|
N/A | |
Completed |
NCT00740363 -
Sitagliptin in Renal Transplant Recipients
|
Phase 4 | |
Completed |
NCT00436475 -
Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes
|
Phase 1/Phase 2 | |
Completed |
NCT04090788 -
The Effect of Momordica Charantia Supplementation on Blood Glucose Levels
|
N/A | |
Active, not recruiting |
NCT05460884 -
Effects of Seaweed Extract on Postprandial Response to White Bread
|
N/A | |
Not yet recruiting |
NCT05462834 -
Impact of Nocturnal Hypoxemia on Glucose in High Altitude Sleep Disordered Breathing
|
N/A | |
Completed |
NCT03348020 -
Iron and Insulin Resistance in Overweight and Obese Humans
|
N/A | |
Terminated |
NCT03356873 -
Impact of Correction of Vitamin D Deficiency in Oxidative Stress in Patients With Prediabetes (VICOX)
|
N/A | |
Completed |
NCT03730727 -
Exercise-meal Timing and Postprandial Glucose Control
|
N/A | |
Completed |
NCT04743960 -
Assessing Metabolic and Sleep Consequences of Overnight Home Parenteral Nutrition
|
N/A | |
Completed |
NCT04004273 -
Diabetes, Exercise and Liver Fat (DELIVER)
|
N/A | |
Terminated |
NCT01887691 -
Sleep Effectiveness and Insulin and Glucose Homeostasis
|
Phase 1 | |
Completed |
NCT02412995 -
The Effects of Sea Buckthorn and Strawberry on Postprandial Glycaemia, Insulinemia and Appetite
|
Phase 0 | |
Not yet recruiting |
NCT01436448 -
Probiotics (Lactobacillus Rhamnosus) in Reducing Glucose Intolerance During and After Pregnancy
|
Phase 3 | |
Completed |
NCT00862589 -
Glucagon-Like Peptide-1 (GLP-1) Suppression of Alpha Cell Secretion in Type 2 Diabetes Mellitus (T2DM)
|
N/A |