Glucose Intolerance Clinical Trial
— GLYCEMIAOfficial title:
Control of Postprandial Glycemia: the Roles of Diet and Exercise
Verified date | April 2019 |
Source | University of Michigan |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Specific aims of the study are:
1. to evaluate whether a 24-h exposure to a 25%-carbohydrate diet will reduce postprandial
glycemia to the same extent in the evening (19 h) as in the morning (7 h),. and
2. to determine whether one hour of post-meal moderate intensity exercise (at 50% of
maximal effort) will further reduce postprandial glycemia.
The outcome measures are: plasma concentrations of glucose, insulin,
glucose-dependent-insulinotropic peptide (GIP), leptin, and the ketone body
beta-hydroxybutyrate.
Status | Completed |
Enrollment | 8 |
Est. completion date | April 2019 |
Est. primary completion date | August 31, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 50 Years to 65 Years |
Eligibility |
Inclusion Criteria: - postmenopausal - normal blood glucose - no cholesterol medication - age between 50 an 65 years - overweight but not obese - BMI between 25 and 30 kg/m2 - weight-stable during past 6 months - exercise less than 20 minutes three times a week Exclusion Criteria: - metabolic disease other than hormonally-corrected hypothyroidism - musculo-skeletal disability that would preclude exercise - smoker - do not meet inclusion criteria |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University of Michigan | Northern Michigan University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Postprandial glucose concentration | The area under the postprandial glucose curve | Four hours: 19:20 to 23:20 in the evening trials; 7:20 to 11:20 in the morning trials | |
Primary | Postprandial insulin concentration | The area under the postprandial insulin curve | Four hours: 19:20 to 23:20 in the evening trials; 7:20 to 11:20 in the morning trials | |
Secondary | Postprandial glucose-dependent insulinotropic peptide (GIP) concentration | The area under the postprandial GIP curve | Four hours: 19:20 to 23:20 in the evening trials; 7:20 to 11:20 in the morning trials | |
Secondary | Postprandial beta-hydroxybutyrate concentration | The area under the beta-hydroxybutyrate postprandial curve | Four hours: 19:20 to 23:20 in the evening trials; 7:20 to 11:20 in the morning trials | |
Secondary | Postprandial leptin concentration | The area under the leptin postprandial curve | Four hours: 19:20 to 23:20 in the evening trials; 7:20 to 11:20 in the morning trials |
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