Total Lymphoid Irradiation (TLI) to Prevent Focal Segmental Glomerulosclerosis (FSGS)Recurrence in the Renal Graft

Glomerulosclerosis, Focal Clinical Trial

Official title: Phase 1 Study of TLI Pretransplant to Prevent Recurrence of FSGS in the Graft

Status Completed

Clinical Trial Summary

The purpose was study the immunosuppression using total lymphoid irradiation plus Csa, MMF and prednisone pretransplant to prevent focal segmental glomerulosclerosis recurrence in the renal graft

Clinical Trial Description

Focal and segmental glomerulosclerosis (FSGS) is resistant to treatment with immunosuppressants and after transplant, 40% of such patients have recurrences in renal allograft. The purpose of this trial was to use Total Lymphoid Irradiation (TLI) plus mycophenolate mofetil (MMF), cyclosporine A (CsA) and prednisone (PRED) to prevent recurrence. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Glomerulosclerosis, Focal
• Glomerulosclerosis, Focal Segmental
• Recurrence

• NCT number: NCT00353535
• Study type: Interventional
• Source: University of Sao Paulo
• Status: Completed
• Phase: Phase 1
• Start date: January 2000
• Completion date: December 2002