Glomerulosclerosis, Focal Clinical Trial
Official title:
Phase 1 Study of TLI Pretransplant to Prevent Recurrence of FSGS in the Graft
The purpose was study the immunosuppression using total lymphoid irradiation plus Csa, MMF and prednisone pretransplant to prevent focal segmental glomerulosclerosis recurrence in the renal graft
Focal and segmental glomerulosclerosis (FSGS) is resistant to treatment with immunosuppressants and after transplant, 40% of such patients have recurrences in renal allograft. The purpose of this trial was to use Total Lymphoid Irradiation (TLI) plus mycophenolate mofetil (MMF), cyclosporine A (CsA) and prednisone (PRED) to prevent recurrence. ;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
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Recruiting |
NCT01240564 -
The Nephrotic Syndrome Study Network (NEPTUNE)
|
N/A | |
Completed |
NCT00135811 -
Focal Segmental Glomerulosclerosis Clinical Trial (FSGS-CT)
|
Phase 3 | |
Completed |
NCT00404833 -
Mycophenolate Mofetil in Membranous Nephropathy and Focal Segmental
|
Phase 3 |