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Clinical Trial Summary

The purpose was study the immunosuppression using total lymphoid irradiation plus Csa, MMF and prednisone pretransplant to prevent focal segmental glomerulosclerosis recurrence in the renal graft


Clinical Trial Description

Focal and segmental glomerulosclerosis (FSGS) is resistant to treatment with immunosuppressants and after transplant, 40% of such patients have recurrences in renal allograft. The purpose of this trial was to use Total Lymphoid Irradiation (TLI) plus mycophenolate mofetil (MMF), cyclosporine A (CsA) and prednisone (PRED) to prevent recurrence. ;


Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT00353535
Study type Interventional
Source University of Sao Paulo
Contact
Status Completed
Phase Phase 1
Start date January 2000
Completion date December 2002

See also
  Status Clinical Trial Phase
Recruiting NCT01240564 - The Nephrotic Syndrome Study Network (NEPTUNE) N/A
Completed NCT00135811 - Focal Segmental Glomerulosclerosis Clinical Trial (FSGS-CT) Phase 3
Completed NCT00404833 - Mycophenolate Mofetil in Membranous Nephropathy and Focal Segmental Phase 3