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Clinical Trial Summary

Conduct a multicenter, open label Phase IIA trial of oral DCA in 40 surgical patients with recurrent GBM who have clinically indicated debulking surgery planned. No patients will be recruited at UF. Patients will be genotyped to establish safe dosing regimens and will be randomized to receive DCA (N=20) or no DCA (N=20) for one week prior to surgery. Deidentified blood and tumor tissue obtained at surgery will be assessed at UF for biochemical markers of DCA dynamics.

Clinical Trial Description

Evaluate effects of dichloroacetate (DCA) on tumor PDC phosphorylation. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05120284
Study type Interventional
Source University of Florida
Contact Peter W Stacpoole, PhD, MD
Phone 352-273-9023
Email [email protected]
Status Not yet recruiting
Phase Phase 2
Start date March 2022
Completion date June 2025

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