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Glenohumeral Osteoarthritis clinical trials

View clinical trials related to Glenohumeral Osteoarthritis.

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NCT ID: NCT06269705 Recruiting - Clinical trials for Glenohumeral Osteoarthritis

ZILRETTA in Subjects With Glenohumeral Osteoarthritis

Start date: February 5, 2024
Phase: Phase 3
Study type: Interventional

Primary Objective: To assess the efficacy of ZILRETTA on pain following an intra-articular (IA) injection in subjects with glenohumeral osteoarthritis (OA) relative to normal saline placebo Secondary Objective: - To assess the efficacy of ZILRETTA on pain following an IA injection in subjects with glenohumeral OA relative to triamcinolone acetonide injectable suspension, immediate release (TCA-IR) and normal saline placebo - To assess the safety of ZILRETTA in subjects with glenohumeral OA relative to normal saline placebo and TCA-IR

NCT ID: NCT06171542 Active, not recruiting - Clinical trials for Shoulder Osteoarthritis

Efficacy of a Single Image Guided Injection of CTM for Glenohumeral Arthritis

HC22-1
Start date: December 22, 2022
Phase: Phase 1
Study type: Interventional

CTM Biomedical markets and distributes decellularized particulate human placental connective-tissue matrix products, intended solely for homologous use to supplement or replace damaged or inadequate connective-tissue. These are structural tissue allografts processed according to the criteria contained in 21CFR 1271.10(a) for regulation solely under section 361 of the Public Health Service Act. The goal of this study is to determine the success rate of a single, image guided glenohumeral CTM injection (for radiographically confirmed glenohumeral osteoarthritis at follow up intervals of 1, 2, 3, 4, 6, 9, and 12 months. This will be measured using the Likert Pain Scale (LPS) and Oxford Shoulder Score (OSS). Secondary goals are to identify if certain demographic or imaging factors exist that predict early symptom recurrence requiring additional intervention, defined as a second connective tissue matrix injection, a subsequent corticosteroid injection, or arthroplasty.

NCT ID: NCT06043544 Completed - Clinical trials for Glenohumeral Osteoarthritis

Hymovis® Intra-articular Injections vs Corticosteroids Intra-articular Injections in Patients Affected by Glenohumeral Osteoarthritis:

Start date: May 2, 2021
Phase: Phase 4
Study type: Interventional

This monocentric randomized open-label study aims to assess the efficacy and safety of a treatment with medium molecular weight hyaluronic acid (HA) compared to a treatment with corticosteroids on patients affected by glenohumeral osteoarthritis.

NCT ID: NCT05847062 Recruiting - Clinical trials for Glenohumeral Osteoarthritis

Clinical Trial to Analyze Lateralized Models and Medializations of Inverted Arthroplasty.

Start date: March 8, 2022
Phase: N/A
Study type: Interventional

To determine the functional outcomes, complications and muscle performance by isokinetic study of two reverse arthroplasty systems (one with medialized center of rotation and the other with lateralized center of rotation) in the treatment of rotator cuff arthropathies or irreparable cuff tears.

NCT ID: NCT04845074 Recruiting - Clinical trials for Glenohumeral Osteoarthritis

Prosthesis Versus Active Exercise Program in Patients With Glenohumeral Osteoarthritis

PROACT
Start date: June 2, 2021
Phase: N/A
Study type: Interventional

Anatomical total shoulder arthroplasty (TSA) is a well-established treatment for pronounced glenohumeral osteoarthritis. However, the effectiveness of TSA has not been compared to non-surgical treatment in a randomised controlled trial. Shoulder exercises may be an effective treatment for reducing pain and improving function in glenohumeral osteoarthritis. The primary aim of this trial is to examine if TSA followed by standard postsurgical rehabilitation is superior to a 12-week exercise programme in patients with primary glenohumeral OA eligible for unilateral TSA. We hypothesise that surgical intervention followed by standard rehabilitation, results in clinically relevant (18-point, on a scale from 0-100) improvement compared to the exercise intervention.

NCT ID: NCT04105478 Recruiting - Clinical trials for Glenohumeral Osteoarthritis

Comparison of Stemless and Stemmed Shoulder Arthroplasty for Osteoarthritis

Start date: March 1, 2020
Phase: N/A
Study type: Interventional

This is a randomized controlled trial comparing the Comprehensive Nano stemless total shoulder arthroplasty (intervention group) with the Comprehensive un-cemented stemmed total shoulder arthroplasty (control group). All Danish citizens with glenohumeral osteoarthritis indicating a total shoulder arthroplasty referred to the orthopedic department at Copenhagen University Hospital in Gentofte will be offered participation in the trial. The following exclude from participation in the study: below 18 years of age; cognitive or linguistic impairment; insufficient function of the rotator cuff; poor bone quality and ASA group 4-5. A total of 122 patients will be included of which 56 will be part of radiostereometric analysis (RSA) study of humeral component migration. This will allow a maximum of 20% drop out. The primary outcome is magnitude and pattern of migration of the humeral component assessed by RSA. The secondary outcomes are patient-reported outcomes, functional outcome, readmission, complications, revisions, changes in bone mineral density (BMD) of the proximal humerus assessed by duel energy x-ray absorptiometry (DXA) and economy (cost utility analysis). To avoid bias in some of these outcomes, the patient will not know what type of humeral component was used. The patients are examined before the operation and 3, 6, 12 and 24 months after the operation.

NCT ID: NCT03869229 Recruiting - Osteoarthritis Clinical Trials

Adipose-derived Mesenchymal Stem Cells in Osteoarthritis

Start date: April 5, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

This phase I/II study will enroll 100 subjects with mild to moderate osteoarthritis of the hip/knee/glenohumeral joints will be enrolled according to strict inclusion and exclusion criteria. Subjects will receive a single dose of at least 10 million of autologous Adipose-derived Mesenchymal Stem Cells (ADMCS) every three months for 12 months (maximum four doses in total and at least 40 million of ADMCS in total) via ultrasound guided intra-articular injection.

NCT ID: NCT03866330 Recruiting - Osteoarthritis Clinical Trials

Wharton's Jelly-derived Mesenchymal Stem Cells in Osteoarthritis

Start date: March 1, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

This phase I/II study will enroll 100 subjects with mild to moderate osteoarthritis of the hip/knee/ glenohumeral joint will be enrolled according to strict inclusion and exclusion criteria. Subjects will receive every three months a single dose of at least 10 million of Wharton Jelly derived Mesenchymal Stem Cells (WJMSC) form the Polish Stem Cell Bank for 12 months (maximum four doses in total and at least 40 million of WJMSC in total) via ultrasound guided intra-articular injection.

NCT ID: NCT03586687 Terminated - Clinical trials for Glenohumeral Osteoarthritis

Osteoarthritis Shoulder Injection Study

Start date: July 13, 2018
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine the most effective intraarticular steroid dose for the treatment of glenohumeral osteoarthritis. The investigators aim to randomize patients into low, medium, and high dose groups of injectable corticosteroids as these doses are typically used in the standard of care for our patients. To date there has been no study to evaluate which dose is most efficient with the fewest side effects for glenohumeral osteoarthritis. The investigators objective will be to provide ultrasound guided intraarticular glenohumeral injections of these randomized concentrations and to evaluate pain and function before and following injection with the Shoulder Pain and Disability Index (SPADI). The investigators hypothesize that the low dose steroid will provide equivalent improvement of the pain and function to the medium and high doses, while minimizing side effects.

NCT ID: NCT03379545 Completed - Arthritis Clinical Trials

3D MR Versus 3D CT for Glenohumeral Arthritis

Start date: January 11, 2017
Phase: N/A
Study type: Interventional

This study aims to assess the efficacy of three-dimensional magnetic resonance (MR) compared to three-dimensional computed tomography (CT) imaging. This proposed study is a prospective, unrandomized, single-blinded, self-controlled, and single-armed diagnostic radiological evaluation study.