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Effect of Kron (Citicoline and Nicotinamide Oral Solution) on Patients With Open-angle Glaucoma

Glaucoma Clinical Trial

Official title:
Effect of Kron (Citicoline and Nicotinamide Oral Solution) on Patients With Open-angle Glaucoma

Clinical Trial Summary

Aim of this study is to investigate the administration effects of the combination of citicoline 40mg/ml and nicotinamide 15mg/ml oral solution (Kron®) on short term improvement in inner retinal function, bioelectrical activity of the visual cortex and visual function.

Clinical Trial Description

Prospective, masked, randomized placebo-controlled study to evalute the offect of the oral solution Kron® (citicoline 40mg/ml and nicotinamide 15mg/ml) on patients with a diagnosis of open angle glaucoma and risk of glaucoma progression. Glaucomatous patients with a diagnosis of open angle glaucoma and risk of glaucoma progression who meet the study criteria will be enrolled and randomly assign to the following two arms: 1. Treatment group (TG): 20 patients will receive Citicoline 40 mg/ml + Nicotinamide 15 mg/ml oral solution for 3 months (10 ml/day) 2. Control group (CG): 10 patients will be evaluated as control Once recruited, a clinical evaluator will perform a comprehensive ophthalmologic evaluation at baseline, week 6 and week 12. The following examinations will be done in the following sequence: - Visual acuity - Slit lamp evaluation - PERG - PEV pattern - Tonometry - Visual field - Optical Coherence Tomography - Dilated Fundus examination ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06333236
Study type Interventional
Source ASST Santi Paolo e Carlo
Contact
Status Not yet recruiting
Phase N/A
Start date March 25, 2024
Completion date November 30, 2024
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