Anterior Chamber Angle Examination in Angle Closure Suspect Patients

Glaucoma Clinical Trial

Official title:

Anterior Chamber Angle Examination in Angle Closure Suspect Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05209204
• Other study ID #: AC angle angle closure suspect
• Status: Completed
• Start date: April 1, 2019
• Est. completion date: January 1, 2020

Study information

• Verified date: January 2022
• Source: Minia University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to detect PACG suspects using both AS OCT and Scheimpflug imaging.

Description:

Glaucoma is a form of progressive optic neuropathy and is one of the leading causes of preventable blindness worldwide. The average life span is increasing leading to more individuals developing glaucoma as well as having the disease longer, which makes early detection and management very important.[1] Glaucoma is characterized by loss of retinal ganglion cells (RGCs) recognized as optic nerve head (ONH) changes, corresponding visual field (VF) defects and retinal nerve fiber layer (RNFL) loss. At least 40% of RGCs are lost before the VFs show a defect, hence the emphasis on early diagnosis in the stage of glaucoma suspect.[2] There are two types of glaucoma suspect: Primary Open angle and primary angle closure suspect.(3) Primary angle-closure (PAC) suspects can be detected by the following: the trabecular meshwork can only be seen in 180º or less of anterior chamber angle (AC) by gonioscopy, the intraocular pressure(IOP) remains within normal limits and no structural damage to the optic nerve is present.[4] Time domain Optical coherence tomography (TD-OCT) was initially designed to image the posterior segment and retina, but its capability to generate cross-sectional images of internal biological structures without contacting the ocular surface was quickly adapted to visualize the anterior segment and cornea.[5].

Spectral domain anterior segment OCT (SD-OCT) technology allow visualizing the anterior chamber angle of the eye with high speed and high resolution. Spectral-domain OCT(SD OCT) instruments working at 840 nm can reliably identify fine angle structures such as Schwalbe's line.(6) Scheimpflug imaging also offers non-contact imaging of the anterior segment. Although Scheimpflug photography cannot fully visualize the entire angle, the software available on the Pentacam system (Oculus Optikgeräte, Wetzlar, Germany) provides extrapolated measurements of the anterior chamber volume (ACV), which have shown promise in screening for narrow angles.(7)

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: January 1, 2020
• Est. primary completion date: December 1, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years to 70 Years

Eligibility

Inclusion Criteria:

• Hyperopes. 2-Shallow AC. 3-With gonioscopy carried out under dim-light conditions without indentation ,with the eye in primary position there is inability to visualize = 180° of the posterior trabecular meshwork (TM) in the absence of peripheral anterior 4-IOP = 21 as measured by tonometry. 5-Normal visual field on static automated perimetry (SAP) testing. 5-Normal optic nerve head (ONH) appearance on fundus biomicroscopy. 6-Family history of primary angle closure disease.

Exclusion Criteria:

• 1-Eyes with significant corneal opacity that can impare signal strings of any of the used imaging modalities.

2-Eyes wih history of intraocular surgery (e.g. cataract surgery ,retinal detachment surgery).

3-Eyes with history of laser procedures (e.g.laser peripheral iridotomy). 4-Eyes with anterior segment pathology as iridocyclitis or angle disgenesis 5. Eyes with history of trauma. 6- Eyes with findings suggestive of 2dry cause of glaucoma (e.g. iris or angle neovascularization, any iris or corneal abnormalities, dilated episcleral vessels ).

Related Conditions & MeSH terms

• Glaucoma

Intervention

Diagnostic Test:
• ASOCT
Anterior segment imaging using RTVue XR 100 Avanti OCT platform (Optovue Inc.,Fairmont, CA).
• Pentacam
Anterior segment imaging using Oculus Pentacam HR (Oculus Optikgeräte, Wetzlar, Germany).

Locations

Country	Name	City	State
Egypt	Minia University hospital	Minya

Sponsors (1)

Lead Sponsor	Collaborator
Minia University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Anterior segment parameters as measured by AS-OCT:	Anterior chamber depth (ACD)..	3 months
Primary	Anterior segment parameters as measured by Oculus Pentacam:	Anterior chamber angle (ACA).	3 months
Primary	Anterior segment parameters by ASOCT	Angle opening distance at 750 µm (AOD750).	3 months
Primary	Anterior segment parameters by OCT	Anterior chamber angle (ACA).	3 months
Primary	Pentacam parameters	Anterior chamber volume (ACV).	3 months
Primary	Pentacam parameters by Oculus Pentacam:	Anterior chamber depth (ACD).	3 months