Glaucoma Clinical Trial
— EyesinglecellOfficial title:
Molecular Taxonomy of Surgically-harvested Ocular Tissues Defined by Single-cell Transcriptomics
The surgically-harvested eye tissue (ie. vitreous-retinal proliferative membrane, outflow pathway, retinas, and pterygium) is a complex tissue responsible for maintaining intraocular homeostasis or mediating ocular pathogenesis. Dysfunction of one or more resident cell types within the tissues results in different ocular disorder, leading to vision loss, or even blindness. In this study, we aim to use single-cell RNA sequencing to generate a comprehensive cell atlas of surgically-harvested eye tissues.
Status | Not yet recruiting |
Enrollment | 80 |
Est. completion date | December 31, 2021 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 90 Years |
Eligibility | Inclusion Criteria: 1. Patients with ocular diseases and require surgery intervention. 2. The surgery intervention remove pathological tissue during surgery. 3. Patients consent to the treatment and single-cell sequencing. Exclusion Criteria: 1. Surgically removed eye tissue cannot meet with the quality control of single-cell sequencing (mainly the tissue weight and cell counts); |
Country | Name | City | State |
---|---|---|---|
China | First Affiliated Hospital of Nanjing Medical University | Nanjing | Jiangsu |
Lead Sponsor | Collaborator |
---|---|
The First Affiliated Hospital with Nanjing Medical University |
China,
de Bruijn SE, Fiorentino A, Ottaviani D, Fanucchi S, Melo US, Corral-Serrano JC, Mulders T, Georgiou M, Rivolta C, Pontikos N, Arno G, Roberts L, Greenberg J, Albert S, Gilissen C, Aben M, Rebello G, Mead S, Raymond FL, Corominas J, Smith CEL, Kremer H, Downes S, Black GC, Webster AR, Inglehearn CF, van den Born LI, Koenekoop RK, Michaelides M, Ramesar RS, Hoyng CB, Mundlos S, Mhlanga MM, Cremers FPM, Cheetham ME, Roosing S, Hardcastle AJ. Structural Variants Create New Topological-Associated Domains and Ectopic Retinal Enhancer-Gene Contact in Dominant Retinitis Pigmentosa. Am J Hum Genet. 2020 Nov 5;107(5):802-814. doi: 10.1016/j.ajhg.2020.09.002. Epub 2020 Oct 5. — View Citation
Tan WJ, Meng MW, Ricciardi-Castagnoli P, Tang T, Yee ACS, Lim TS. Single B-cell Genomic Analyses Differentiates Vitreoretinal Lymphoma from Chronic Inflammation. Ophthalmology. 2020 Nov 19. pii: S0161-6420(20)31110-6. doi: 10.1016/j.ophtha.2020.11.018. [Epub ahead of print] — View Citation
van Zyl T, Yan W, McAdams A, Peng YR, Shekhar K, Regev A, Juric D, Sanes JR. Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis. Proc Natl Acad Sci U S A. 2020 May 12;117(19):10339-10349. doi: 10.1073/pnas.2001250117. Epub 2020 Apr 27. — View Citation
Wynne N, Carroll J, Duncan JL. Promises and pitfalls of evaluating retinal diseases with adaptive optics scanning light ophthalmoscopy (AOSLO). Prog Retin Eye Res. 2020 Nov 5:100920. doi: 10.1016/j.preteyeres.2020.100920. [Epub ahead of print] Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | counts of each cell type | single-cell sequencing identify what cells and the counts within the eye tissue | 1 month |
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