Predicting the Effect of Laser Peripheral Iridotomy

Glaucoma Clinical Trial

Official title: Prediction of the Degree of Angle Opening Distance in Patients With Primary Angle Closure Suspect After Laser Peripheral Iridotomy

Status Recruiting

Clinical Trial Summary

This study will compare the angle parameters of patients with PACS before and after LPI. The investigators will analyze the results of patients with different angle closure mechanisms before and after LPI, and participants hope to find the structural parameters for predicting the effect of LPI.

Clinical Trial Description

Primary angle-closure glaucoma is the leading cause of blindness worldwide. It is associated with increased intraocular pressure, which causes optic nerve damage and field defects if untreated. The aqueous humor leaves the anterior chamber through the trabecular meshwork and flows into the aqueous vein and the superior scleral vein through the collector channels and Schlemm's canal. If the trabecular meshwork is not blocked, a wide angle allows enough aqueous humor to drain out. The iris corneal translocation may lead to angle-closure glaucoma.

Laser peripheral iridectomy is recognized as the best surgical method to relieve pupil block. Previous studies have shown increased anterior chamber depth (ACD), area (ACA), and volume (ACV), and increased Angle open distance (AOD) after LPI surgery.

However, postoperative outcomes of LPI were not the same for patients with different angle closure mechanisms.

Postoperative outcomes for LPI were best for patients with pupillary block type, but were moderate for patients with plateau iris group and mixed group.

The purpose of this study, conducted in Chinese subjects, aims to use UBM to evaluate changes in the anterior segment parameters of LPI, and to propose methods to predict postoperative outcomes of LPI. ;

Related Conditions & MeSH terms

• Glaucoma

• NCT number: NCT04495491
• Study type: Observational [Patient Registry]
• Source: Zhongshan Ophthalmic Center, Sun Yat-sen University
• Contact: Yuying Zhou, Master
• Phone: 8615270988097
• Email: 2053552500@qq.com
• Status: Recruiting
• Start date: July 1, 2020
• Completion date: March 31, 2021