Glaucoma Clinical Trial
Official title:
Segmental Analysis of Retinal Layers and Measurement of Lamina Cribrosa Thickness in Patients With Asymmetric Primary Open-Angle Glaucoma
The study aims to further understand glaucoma pathogenesis and progression by utilizing enhanced depth imaging optical coherence tomography to visualize and measure lamina cribrosa in vivo and segmentation technology to accurately delineate and measure boundaries of the retinal layers. Investigators will elaborate further on key concepts of lamina cribrosa thickness and trans-synaptic degeneration.
Two important areas of the eye that need investigation in order to further understanding of
glaucoma. First is the retina (part of the eye that converts images from the eye's optical
system into electrical impulses sent along the optic nerve to the brain). Newer technology,
Spectral Domain Optical Coherence Tomography (SD-OCT), allows us to look at different layers
of the retina and carefully measure thickness of each layer. Second area is lamina cribrosa
(a portion of the white part of the eye which has nerve fibers passing through it connecting
the eye to the brain). If lamina cribrosa is thin, it is possible it may bend easily and
disrupt nerve fibers. SD-OCT allows measurement of lamina cribrosa thickness.
Findings will help monitor changes that occur in the eye as a result of glaucoma.
Individuals with primary open-angle glaucoma and unilateral visual field defects were chosen
as the main patient population (in addition to normal controls). By approximating each
participants baseline anatomy using the fellow, "internal control" eye, investigators will be
able to better determine if any changes occur in the macula or the lamina cribrosa as a
result of glaucoma.
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