Glaucoma Clinical Trial
Official title:
Reversible Structural and Functional Changes After Intraocular Pressure Reduction in Patients With Glaucoma
The aim of this study was to evaluate structural and functional improvement after lowering intraocular pressure (IOP) in patients with glaucoma using Spectral Domain Optical Coherence Tomography (SD-OCT), Visual Field (VF) testing, and Visual Evoked Potential (VEP).
Glaucoma exhibits characteristic changes to the optic nerve in the back of the eye. The optic
nerve is formed when fibers that overlay the retina come together. This layer is called the
retinal nerve fiber layer (RNFL).
Optical Coherence Tomography (OCT) is a machine that scans eyes and has the capability of
measuring thickness of various layers in the retina and RNFL. This provides important
anatomical information.
VEP (visual evoked potential) is an imaging system that measures electrical signals from the
eye to the brain by using electrodes placed on the forehead and back of head. This is similar
in principal to an electrocardiogram of the heart.
Visual field testing is done to evaluate the extent of side vision loss caused by various
diseases of the eye, including glaucoma. This testing is performed as you stare at a small
light directly in front of your eye while lights flash one at a time in every direction on a
screen surrounding the central light. You push a button each time you see a flash out of the
corner of your eye.
Lowering intraocular pressure (IOP) in the eye has been shown to result in reversal of
glaucoma changes of the optic nerve in some patients. It has also been suggested that
improvement in function (visual field) has been associated with improved optic nerve
appearance.
This study seeks to provide evidence for reversal of disc appearance and visual function
following IOP lowering interventions.
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