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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02544646
Other study ID # OPHT-040411
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date October 13, 2011
Est. completion date June 8, 2017

Study information

Verified date February 2020
Source Medical University of Vienna
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

It has been hypothesized that the biomechanical properties of the optic nerve head and/or sclera play a role in the development of glaucoma. One approach of gaining insight into the biomechanical properties of the eye by the means of clinical studies is based on the Friedenwald equation, representing a pressure-volume relationship. This equation represents the so called ocular rigidity, which expresses the elasticity of the globe.

In order to be able to solve the equation, measurements of fundus pulsation amplitude (FPA) with laser interferometry and dynamic contour tonometric assessment of the pulse amplitude (PA) have to be performed.

In addition choroidal thickness will be assessed with OCT before and after trabeculectomy, since results in choroidal thickness measurements in patients with glaucoma are controversial.

The focus of this study lies on the changes of ocular rigidity and choroidal thickness after surgical trabeculectomy in patients with primary open angle glaucoma (POAG) or pseudoexfoliation glaucoma (PEX).


Recruitment information / eligibility

Status Completed
Enrollment 53
Est. completion date June 8, 2017
Est. primary completion date June 8, 2017
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Men and women aged over 18 years

- Normal ophthalmic findings except POAG or Pseudoexfoliation glaucoma (PEX)

- Patients scheduled for trabeculectomy

Exclusion Criteria:

- Participation in a clinical trial in the 3 weeks preceeding the study

- Symptoms of a clinically relevant illness in the 3 weeks before the first study day

- Presence or history of a severe medical condition that will interfere with the study aim as judged by the clinical investigator

- Other types of glaucoma, such as pigmentary glaucoma, history of acute angle closure

- History of previous glaucoma surgery

- Postoperative IOP = 8 mmHg

- Ocular inflammation or infection within the past 3 months

- Topical treatment with any ophthalmic drug except anti-glaucomatous medication

Study Design


Intervention

Other:
Changes in Ocular rigidity
measured before the operation and 28±7 days after the operation

Locations

Country Name City State
Austria Department of Clinical Pharmacology, Medical University of Vienna Vienna

Sponsors (1)

Lead Sponsor Collaborator
Medical University of Vienna

Country where clinical trial is conducted

Austria, 

Outcome

Type Measure Description Time frame Safety issue
Primary Change in ocular rigidity Change in ocular rigidity after surgery Baseline and 28±7 days postoperative
Secondary Fundus pulsation amplitude Baseline and 28±7 days postoperative
Secondary Ocular pulse amplitude Baseline and 28±7 days postoperative
Secondary Mean arterial pressure Baseline and 28±7 days postoperative
Secondary Pulse rate Baseline and 28±7 days postoperative
Secondary Axial eye length Baseline and 28±7 days postoperative
Secondary choroidal thickness Baseline and 28±7 days postoperative
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