Comparing the Effect of the Water Drinking Test on Intraocular Pressure

Glaucoma Clinical Trial

Official title:

Comparing the Effect of the Water Drinking Test on Intraocular Pressure in Patients With Prior Trabeculectomy or Tube Shunt Surgeries

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02001155
• Other study ID #: WEH - 10-989E
• Status: Completed
• Phase: N/A
• First received: November 26, 2013
• Last updated: November 8, 2016
• Start date: July 2013
• Est. completion date: July 2014

Study information

• Verified date: November 2016
• Source: Wills Eye
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

A test that was common in the 1960's and was used to detect primary open angle glaucoma was the water drinking test (patients drank 1 quart of water to stress the fluid drainage mechanism of the eyes. Intraocular pressure was then measured over the next hour). Recently this test has been demonstrated as a predictor of peak eye pressure during the day. The purpose of this study is to compare the results of the water drinking test between eyes that have undergone trabeculectomy and eyes that have undergone tube shunt surgery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: July 2014
• Est. primary completion date: February 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 21 Years to 90 Years

Eligibility

Inclusion Criteria:

• prior trabeculectomy or tube shunt for the treatment of glaucoma

• age 21-90 years

Exclusion Criteria:

• inability to give informed consent

• current ocular infection

• more than 1 prior trabeculectomy, or more than 1 prior tube shunt

• previous refractive surgery

• pregnant women

• heart failure

• renal failure or uncontrolled urine retention

• corneal abnormalities preventing reliable IOP measurement

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Glaucoma

Intervention

Procedure:
• Water Drinking Test
The Water Drinking test has been identified as a reliable and safe tool to predict maximum intraocular pressure values during a diurnal tension curve and to assess the efficacy of surgical interventions. Participants are asked to drink 10 ml/kg water (or approximately 0.33 ounces of water for every 2.2 pounds of weight or about 2.5 cups for a 150 lb. individual) over 15 minutes. Intraocular pressure is assessed every 15 minutes for one hour.

Locations

Country	Name	City	State
United States	Wills Eye Hospital	Philadelphia	Pennsylvania

Sponsors (1)

Lead Sponsor	Collaborator
Wills Eye

Country where clinical trial is conducted

United States, 

References & Publications (1)

Waisbourd M, Savant SV, Sun Y, Martinez P, Myers JS. Water-drinking test in primary angle-closure suspect before and after laser peripheral iridotomy. Clin Exp Ophthalmol. 2016 Mar;44(2):89-94. doi: 10.1111/ceo.12639. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Intraocular Pressure (IOP)	IOP is assessed every 15 minutes for one hour after the water drinking test is complete.	1 hour	No