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Continuous Intraocular Pressure (IOP) Measurement and Ability to Detect Treatment Effect

Glaucoma Clinical Trial

Official title:
Evaluation of Continuous IOP Measurement and the Influence of Drug Induced IOP Decrease on the Measurement

Clinical Trial Summary

Continuous intraocular pressure (IOP) measurement with a contact lens sensor may provide more information on the drug-related IOP change than 24-hour IOP measurement with Goldmann applanation tonometry (GAT.

Clinical Trial Description

- Participants are washed ot from all glaucoma medication for 6 weeks

- one eye per participant is investigated (study eye)

- 24-h intraocular pressure (IOP) curve is obtained with Goldmann tonometry and Sensimed contact lens sensor tonometry twice, in 14 days

- for Sensimed contact lens curves median values (in arbitrary units), for Goldmann applanation tonometry, mean and SD values are used to characterize the curves, for comparisions % changes are used for the corresponding time periods

- treatment (travoprost 0.005% 1/day) is given to all eyes for 3 months 24-h Goldmann and Sensimed IOP curves are repeated

- IOP curves are determined in arbitrary units and mmHg, respectively, and compared for reproducibility (untreated phase) and relative (%)change (untreated curve vs. under treatment curve) with both methods, respectively ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01491867
Study type Interventional
Source Semmelweis University
Contact
Status Completed
Phase N/A
Start date December 2011
Completion date October 2012
View Details
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