Glaucoma Clinical Trial
Official title:
Assessment of Advanced Glaucomatous Visual Field Loss and Its Impact on Visual Exploration, Activities of Daily Living (ADL) and Quality of Life (QoL)
The purpose of this explorative study, targeting subjects with advanced binocular
glaucomatous visual field loss, is: (i) to identify the perimetric / psychophysical method,
that is most closely correlated with an individually assessed quality of life (QoL) score,
using a validated questionnaire (NEI-VFQ 25), (ii) to determine, whether gaze-related
(exploratory eye movements) or visual field-related (eyes steadily fixating) OR
attention-related parameters are better for the characterization of the visual capacities
that are necessary for activities of daily living (ADL), as represented (iia) by a
standardized visual search task and (iib) by an on-road car driving feasibility study.
Further this study is intended to introduce and analyse a novel diagnostic method for
recording and evaluating exploratory eye movements (gaze-related perimetry) in a clinical
setting. A similar procedure has recently been introduced by Murray et al. However, their
set-up is based on a video monitor and, therefore, restricted to the central visual field
(eccentricity < 25°) and limited with regard to the dynamic range of the stimulus luminance.
Since our new gaze-related perimetry is designed to be implemented in a conventional cupola
perimeter, it should be widely available as a potent diagnostic tool, for screening
purposes, or for clinical surveys by general ophthalmologists or clinical research groups.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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