Comparison of Critical Flicker Fusion Versus Automated Visual Fields in the Detection of Early Glaucoma

Glaucoma Clinical Trial

Official title:

Comparison of Critical Flicker Fusion vs. Automated Visual Fields in the Detection of Early Glaucoma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01076114
• Other study ID #: 09-320
• Status: Completed
• Phase: N/A
• First received: February 24, 2010
• Last updated: March 14, 2011
• Start date: February 2010
• Est. completion date: February 2011

Study information

• Verified date: March 2011
• Source: Northwell Health
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to evaluate if critical flicker fusion is a more reliable method for detection of early glaucoma compared to automated visual fields in comparison to subjects without evidence of glaucoma or optic nerve disease.

Description:

Our hypothesis is that critical flicker fusion (CFF) is a more reliable method for detection of early glaucoma compared to automated visual fields in comparison to subjects without evidence of glaucoma or optic nerve disease. We aim to evaluate the structure of the optic nerve and compare it to results of visual fields and CFF. The CFF will also be correlated with intraocular pressure (IOP) measurements to observe if it may be more closely related than visual fields. This may become an additional tool to detect glaucoma in those with unreliable visual fields or who are unable to perform a visual field from physical or mental limitations.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 58
• Est. completion date: February 2011
• Est. primary completion date: February 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion:

• Glaucoma Suspects:

• Abnormal optic disc appearance with increased cup to disc ratio, or

• Increased intraocular pressure >21 in either eye

• Control Subjects:

• Normal appearing optic discs

• Normal intraocular pressure (<21)

Exclusion:

• Other ocular pathology

• History of seizures or epilepsy

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Glaucoma

Locations

Country	Name	City	State
United States	Nassau University Medical Center	East Meadow	New York

Sponsors (2)

Lead Sponsor	Collaborator
Northwell Health	Nassau University Medical Center

Country where clinical trial is conducted

United States, 

References & Publications (11)

Chang TT, Ciuffreda KJ, Kapoor N. Critical flicker frequency and related symptoms in mild traumatic brain injury. Brain Inj. 2007 Sep;21(10):1055-62. — View Citation

Chen PC, Woung LC, Yang CF. Modulation transfer function and critical flicker frequency in high-myopia patients. J Formos Med Assoc. 2000 Jan;99(1):45-8. — View Citation

Javitt JC, McBean AM, Nicholson GA, Babish JD, Warren JL, Krakauer H. Undertreatment of glaucoma among black Americans. N Engl J Med. 1991 Nov 14;325(20):1418-22. — View Citation

Matsumoto C, Takada S, Okuyama S, Arimura E, Hashimoto S, Shimomura Y. Automated flicker perimetry in glaucoma using Octopus 311: a comparative study with the Humphrey Matrix. Acta Ophthalmol Scand. 2006 Apr;84(2):210-5. — View Citation

Patterson VH, Foster DH, Heron J, Mason RJ. Multiple sclerosis. Luminance threshold and measurements of temporal characteristics of vision. Arch Neurol. 1981 Nov;38(11):687-9. — View Citation

Riddell LA. THE USE OF THE FLICKER PHENOMENON IN THE INVESTIGATION OF THE FIELD OF VISION. Br J Ophthalmol. 1936 Jul;20(7):385-410. — View Citation

Sharma P, Sharma BC, Tyagi P, Kumar M, Sarin SK. Neuropsychological impairment in severe acute viral hepatitis is due to minimal hepatic encephalopathy. Liver Int. 2009 Feb;29(2):260-4. doi: 10.1111/j.1478-3231.2008.01856.x. Epub 2008 Aug 14. — View Citation

Tielsch JM, Sommer A, Katz J, Royall RM, Quigley HA, Javitt J. Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey. JAMA. 1991 Jul 17;266(3):369-74. — View Citation

Tyler CW. Specific deficits of flicker sensitivity in glaucoma and ocular hypertension. Invest Ophthalmol Vis Sci. 1981 Feb;20(2):204-12. — View Citation

Van Toi V, Grounauer PA, Burckhardt CW. Artificially increasing intraocular pressure causes flicker sensitivity losses. Invest Ophthalmol Vis Sci. 1990 Aug;31(8):1567-74. — View Citation

Yoshiyama KK, Johnson CA. Which method of flicker perimetry is most effective for detection of glaucomatous visual field loss? Invest Ophthalmol Vis Sci. 1997 Oct;38(11):2270-7. — View Citation

* Note: There are 11 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Difference of mean deviation of glaucoma suspects from controls between critical flicker fusion and automated visual fields.		1 visit (1 day)	No