Intraocular Pressure (IOP) Lowering Effect of Selective Laser Trabeculoplasty Versus Prostaglandin Analogues in Angle Closure Glaucoma

Glaucoma Clinical Trial

Official title: Comparison of Selective Laser Trabeculoplasty With Prostaglandin Analogues for Lowering Intraocular Pressure in Eyes With Primary Angle Closure Glaucoma

Status Recruiting

Clinical Trial Summary

Glaucoma affects 66 million people worldwide and is the leading cause of irreversible blindness, and Primary angle-closure glaucoma (PACG) is a major form of glaucoma in Asia.

Laser peripheral iridotomy (LPI) has been advocated as the first line treatment in all cases of PACG. In addition to relieving the relative pupil block element of the condition, it can open up the drainage angle, alleviating appositional and synechial angle-closure and in the long-term this may control intraocular pressure (IOP) and prevent progression of glaucomatous optic neuropathy. However recent data indicate that iridotomy is not successful in controlling IOP in the long term, and the majority of cases develop a clinically significant rise in IOP requiring medical therapy or surgery.

Laser trabeculoplasty has been a recognized treatment option for Primary open angle glaucoma (POAG) since the 1980s. Recently a more selective and less destructive method of performing laser trabeculoplasty has evolved. Selective Laser Trabeculoplasty (SLT) specifically targets the pigmented trabecular meshwork cells without producing collateral damage and destruction to adjacent structures. Morphologic study performed on human autopsy eyes treated with SLT noted no structural or collateral thermal damage to the trabecular beams in the uveal and corneoscleral meshwork. As SLT specifically has its effect on the targeted pigmented trabecular meshwork it is unlikely to generate PAS. It may be a useful treatment option for PACG patients in whom the angle has widened following laser peripheral iridotomy.

The proposed study is a randomized controlled trial to assess the effectiveness of SLT in reducing IOP in cases of PACG in which the angle has opened up following LPI, but IOP remains high(>21 mmHg). 100 subjects will be randomized to receive either SLT or medical treatment to achieve IOP control. They will be followed up for 6 months.

Clinical Trial Description

STUDY OBJECTIVES AND PURPOSE

The aim of this study is to determine whether selective laser trabeculoplasty (SLT) is an effective treatment for lowering intraocular pressure (IOP) in patients with primary angle closure glaucoma (PACG), compared to prostaglandin analogues, the current first choice IOP-lowering medical therapy.

STUDY DESIGN The study design for this project is a prospective randomized controlled trial. It will not be possible to blind either the subject or observer to the intervention due to the use of laser in the intervention group and medical therapy in the control group. Subjects will then be followed-up for 6 months

STUDY POPULATION

The study population will be patients with primary angle closure glaucoma attending the Singapore National Eye Centre, who fulfil the inclusion criteria and are willing to take part in the study.

WASH OUT REGIMEN: for patients already on medication

Eligible patients who are already on one or two-glaucoma medications are required to complete a washout period before being randomized. Washout periods will vary according to the previous medication used and are as follows:

Prostaglandin analogues 4 weeks Beta blockers 3 weeks Adrenergic agonist 2 weeks Cholinergic agonist 5 days Carbonic Anhydrase Inhibitors 5 days

Pre-study washout period check Patients who are on prostaglandin analogues or beta blockers prior to the study will be required to undergo a washout period of 3 and 4 weeks respectively prior to the study. For this group of patients, there will be a safety check during the second week. Patients whose IOP>30 mm hg during this washout check will be stopped from further washout and be withdrawn from the study.

Treatment of subjects

PLANNED INTERVENTION

Selective laser trabeculoplasty procedure The laser procedure will be performed on all patients as follows

• A drop of Brimonidine will be instilled into the eye to be treated 15 minutes prior to the procedure.

• Topical anaesthesia will be administered and the Latina SLT lens and coupling fluid will be used for the procedure.

• The slit-lamp attached to the laser will be focused on the full height of the trabecular meshwork.

• The laser power will be set to 0.6mJ and increased in 0.1mJ steps until small champagne -like bubbles appear from the treated area of the trabecular meshwork. The laser spot size would be 400µm.

• Approximately 60-120 non-overlapping shots will be placed onto at least 180 degrees of the trabecular meshwork that is visible and without PAS. More non-overlapping shots can be placed if sufficient extent of the trabeculum is visible.

Post - laser the patient will be given a one week course of topical Prednisolone forte four times a day for the treated eye.

Intraocular pressure will be checked 30-60 minutes after the procedure. IOP spikes of ≥ 5mmHg or to a level of ≥ 28mmHg will be treated with Diamox if not contraindicated.

Intraocular pressure will be checked one week post SLT. If the IOP ≥28mmHg, tablet diamox will be given for 3 days.

Retreatment of SLT If IOP remains elevated, one further treatment of SLT will be given to the patient. This treatment will be administered either at the four week or three month follow up visit.

If there is a <20% reduction of IOP from baseline either at the week 4 or month 3 follow-up visit, then SLT will be repeated using the same laser parameters as described above. The patient will be seen again one week after the repeated laser treatment.

IIf the IOP is <21mmHg or there is >20% reduction of IOP from baseline at at the week 4 or month 3 follow-up visit, then no further treatment will be given to the patient.

IOP will be checked one week after repeat SLT. If the IOP is still high (>24 mmHg), treatment modification will be provided (see Treatment Modification below).

Control group Those patients randomized to the control group will be commenced on topical treatment to lower the IOP. The agent for lowering IOP will be a prostaglandin analogue, Travoprost, which will be applied once a day at night.

A stepwise addition of Timolol 0.5%, dorzolamide or brimonidine will be implemented until IOP is controlled (see below Treatment Modification). ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Glaucoma
• Glaucoma, Angle-Closure

• NCT number: NCT01004900
• Study type: Interventional
• Source: Singapore Eye Research Institute
• Contact: Tin Aung, FRCOphth
• Phone: 62277255
• Email: aung.tin@snec.com.sg
• Status: Recruiting
• Phase: Phase 3
• Start date: June 2009
• Completion date: March 2011