Multidrug Resistance After Trabeculectomy With Mitomycin C

Glaucoma Clinical Trial

Official title:

Multidrug Resistance After Trabeculectomy With Mitomycin C

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00449631
• Other study ID #: Multidrug Resistance
• Status: Completed
• Phase: N/A
• First received: March 19, 2007
• Last updated: March 23, 2007

Study information

• Verified date: March 2007
• Source: University of Cologne
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Federal Institute for Drugs and Medical Devices
• Study type: Observational

Clinical Trial Summary

We investigate whether mitomycin C treatment during previous filtration surgery induces P-glycoprotein expression.

Description:

Despite the adjuvant use of mitomycin C during trabeculectomy, short-term and long-term failures still occur. We investigate whether mitomycin C treatment during previous trabeculectomy induces P-glycoprotein expression. Expression of P-glycoprotein is analysed in surgically removed Tenon tissue using immunohistochemistry.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 8 Years to 85 Years

Eligibility

Inclusion Criteria:

• patients with planned trabeculectomy for elevated eye pressure

• one third of patients without previous trabeculectomy

• two thirds of patients with previous trabeculectomy (one third with and one third without the use of mitomycin C)

Exclusion Criteria:

• patients not requiring surgery

• patients with planned surgery for elevated eye pressure other than trabeculectomy

Study Design

Primary Purpose: Screening, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Glaucoma
• Trabeculectomy

Locations

Country	Name	City	State
Germany	The University Hospital of Cologne	Cologne

Sponsors (1)

Lead Sponsor	Collaborator
University of Cologne

Country where clinical trial is conducted

Germany,