Glaucoma Clinical Trial
Official title:
Messenger Ribonucleic Acid Expression in Lymphocytes of Glaucoma Patients
Verified date | August 2009 |
Source | University Hospital, Basel, Switzerland |
Contact | n/a |
Is FDA regulated | No |
Health authority | Switzerland: Swissmedic |
Study type | Observational |
The aim of the study is to compare messenger ribonucleic acid (mRNA) expression of various genes in lymphocytes between glaucoma patients and sex and age-matched healthy subjects. A secondary objective is to analyze the impact of different forms of glaucoma or of a vasospastic propensity on the findings.
Status | Completed |
Enrollment | 60 |
Est. completion date | December 2007 |
Est. primary completion date | December 2007 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 85 Years |
Eligibility |
Inclusion Criteria: Glaucoma patients - diagnosis of chronic glaucoma with typical glaucomatous disc and visual field damage - a present or past diurnal tension curve with an average intraocular pressure above 21 mmHg without treatment HTG) - a present or past diurnal tension curve with an average intraocular pressure below 21 mmHg without treatment (NTG) - a present or past diurnal tension curve with an average intraocular pressure above 21 mmHg without treatment and signs of pseudoexfoliation in the anterior segment (PEX) - a juvenile-onset open-angle glaucoma with a present or past diurnal tension curve with an average intraocular pressure above 21 mmHg without treatment (Juvenile Glaucoma) Healthy subjects - no history of ocular disease - no history of systemic disease - no history of alcohol/drug abuse - normal blood pressure (100-140 / 60-90 mmHg) - best corrected visual acuity above 20/25 in both eyes - no pathological findings upon a slit-lamp examination and indirect fundoscopy - IOP < 20 mmHg in both eyes Exclusion Criteria: - Ametropia > 3 dpt - Iridocorneal angle extremely narrow with complete or partial closure as determined by gonioscopy - Pigmentary dispersion - any abnormality which in the physician's view would prevent reliable applanation tonometry - History of chronic or recurrent severe inflammatory eye disease such as scleritis or uveitis - History of ocular trauma or intraocular surgery within the past 6 months - History of infection or inflammation within the past 3 months - History of clinically significant or progressive retinal disease such as retinal degeneration, diabetic retinopathy or retinal detachment - Need for any concomitant medications that may interfere with the evaluation of ocular blood flow - significant history and/or active alcohol or drug abuse |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Switzerland | University Hospital Basel, Eye Clinic | Basel | BS |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Basel, Switzerland | University of Bonn |
Switzerland,
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