Glaucoma, Open-angle Clinical Trial
Official title:
The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure
The aim of this study will be to determine the effects of pilocarpine as an adjunct medication to latanoprost monotherapy at multiple intervals throughout a 24-hour period and compare these effects to latanoprost alone.
This study plans to learn more about the effect of pilocarpine on intraocular pressure and
ocular perfusion pressure for a full twenty-four hour period.
In this study, the investigators seek to better characterize the knowledge base of the
intraocular pressure (IOP) lowering effects of pilocarpine in patients with open angle
glaucoma or ocular hypertension who are currently taking latanoprost. The goal is to define
the potential additive effect of pilocarpine throughout a 24-hour period, not only for IOP,
but for ocular perfusion pressure (defined as 2/3[diastolicBP + 1/3(systolicBP -
diastolicBP)] - IOP). These data will allow to expand current knowledge of the effects of
pilocarpine and help determine if this medication has a useful role as an adjunctive
treatment in glaucoma.
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