Acquired Chronic Erosive Gingivitis: Clinical Relevance of Papillary

Status Completed

Clinical Trial Summary

Chronic erosive gingivitis is a syndrome (CEGS) that combines severe gingival inflammation and gingival erosion. The term "desquamative gingivitis" is often used in the literature to define chronic erosive gingivitis. However, this definition is inappropriate because the pathophysiological process at the origin of this gingival disease does not induce a desquamation but rather a loss of gingival substance, namely erosion, concerned wholly or in part of the gingival epithelium. In most clinical situations, chronic erosive gingivitis is an oral manifestation of a general disease with immune dysfunction. The most frequently described diseases are gingival lichen and autoimmune bullous diseases (AIBD). In 2018, as part of a monocentric study, we were the first to detail an original papillary gingival biopsy protocol, non-iatrogenic, perfectly suited to the anatomopathological examinations necessary for the diagnosis of AIBD gingival expression. The CEGS early detection by odontologists avoid delayed diagnosis and allows patients to be referred to the closest AIBD reference center.

Hypothesis/Objective A bicentric study was conducted, to evaluate the clinical relevance of this protocol, including the differential diagnosis of the CEGS. Research was supplemented by carrying out a systematic review of the literature to compare the contributive capacity diagnostic of the papillary biopsy technique with other gingival sample methods (attached gingival tissue, mucosa).

Method A retrospective bicentric observational study was conducted from October 2011 to July 2019, in two departments of oral medicine of two public hospitals in Paris (University Hospital - Bretonneau in Paris and Henri Mondor in Créteil; France). These two departments are specialized in the diagnosis and management of oral pathology; that of the Henri Mondor hospital is an AIBD reference center.

The literature review was developed in accordance with PRISMA recommendations. It was conducted on Pubmed - MEDLINE and Cochrane Oral Health Group and included all existing publications from 1935 until August 2019. A manual search of publications from the unpublished literature was also conducted.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04293718
Study type	Observational
Source	Assistance Publique - Hôpitaux de Paris
Contact
Status	Completed
Phase
Start date	October 2011
Completion date	July 2019

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT05568290` - Interleukin-38 Levels in Individuals With Periodontitis
Completed	`NCT04402996` - Meteorin-like Levels in Individuals With Periodontitis
Not yet recruiting	`NCT06016023` - Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker
Not yet recruiting	`NCT05497895` - The Assessment of Clinical Efficacy of Topical Application of 5% Thymoquinone Gel for Gingivitis Patients	Early Phase 1
Completed	`NCT02633345` - Effects on Tablets Containing Probiotic Candidate Strains	N/A
Completed	`NCT02552589` - Effect of Toothpaste on the Reduction of Plaque and Inflammation	N/A
Completed	`NCT02884817` - Essential Oil+ELA, Plaque and Gingivitis	Phase 4
Completed	`NCT02235532` - Effects of Aloe Vera Toothpaste on Periodontal Parameters	N/A
Completed	`NCT02980497` - Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study	N/A
Completed	`NCT02515929` - Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs	Phase 4
Unknown status	`NCT01956656` - Efficacy Of Lotus Leaves In Management Of Plaque Induced Gingivitis	N/A
Completed	`NCT01941797` - Experimental Peri-implant Mucositis in Humans	N/A
Completed	`NCT02508987` - Obesity and Oxidative Stress in Patients With Different Periodontal Status	N/A
Unknown status	`NCT01197105` - Evaluation Study of a Mouthwash Based on Schinus Terebinthifolius to Treat Gingivitis in Children	Phase 1/Phase 2
Completed	`NCT01593540` - Clinical Examination of Metal Free Interdental Brushes	Phase 4
Completed	`NCT01236963` - Essential Oils Mouth Rinse and Dental Floss: Efficacy on Interproximal Gingivitis and Dental Plaque Accumulation	N/A
Completed	`NCT02102295` - Effects of Antioxidant Dentifrice on Gingivitis	Phase 3
Completed	`NCT06140784` - A Clinical Study to Assess the Gingivitis and Plaque Effects of Various Dentifrices	N/A
Completed	`NCT02937636` - To Investigate the Gingivitis Efficacy of a Stannous Fluoride Dentifrice in a Chinese Population	N/A
Completed	`NCT06212908` - Assessment of Periodontal Therapy and Biofilm Management in Breast Cancer	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Acquired Chronic Erosive Gingivitis: Clinical Relevance of Papillary Gingival Biopsy

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms