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Gingivitis clinical trials

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NCT ID: NCT05121909 Completed - Gingivitis Clinical Trials

A Study of Experimental Mouthwashes

Start date: November 15, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of experimental mouthwash formulations compared to a hydroalcohol control mouthwash and a positive control mouthwash for the reduction of gingivitis and plaque when used as an adjunct to tooth brushing during a twelve-week product usage period.

NCT ID: NCT05120141 Completed - Gingivitis Clinical Trials

A Twelve Week Study of Experimental Mouth Rinses

Start date: March 29, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of experimental mouth rinse formulations compared to a hydroalcohol control mouth rinse and a positive control mouth rinse for the reduction of gingivitis and plaque when used as an adjunct to tooth brushing during a twelve-week product usage period.

NCT ID: NCT05114681 Completed - Periodontitis Clinical Trials

Oral Health Care in Stroke Patients in Tertiary Care Hospital

Start date: January 1, 2021
Phase:
Study type: Observational [Patient Registry]

To investigate oral care provision in stroke care settings in Pakistan. Stroke can have adverse effects on oral care and health. Little is known about current oral care practices in stroke care settings.

NCT ID: NCT05113030 Completed - Clinical trials for Polycystic Ovary Syndrome

Impact of PCOS on Periodontal Status of Adolescent and Adult Age Group Women

Start date: November 1, 2021
Phase:
Study type: Observational

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women, primarily affecting the reproductive system, with substantial collateral negative health effects on metabolic, psychological, and cardiovascular functions. Patients with this syndrome are at higher risk of developing insulin resistance (IR), obesity, dyslipidemia, cardiovascular disease (CVD), and endometrial carcinoma.IR and hyperinsulinemia are responsible for the low-grade chronic systemic inflammation. Periodontitis, an immuno-inflammatory disease, is a result of interaction between bacterial attack and host inflammatory response, causing inflammation of supporting tissues of the teeth leading to tissue destruction and tooth loss. Chronic low-grade inflammation is emerging as a plausible etiologic mechanism linking periodontal disease and many systemic diseases. Previous cross-sectional studies described a possible relationship between PCOS and periodontitis and the impact of PCOS on gingival inflammation and vice-versa in terms of increased inflammatory markers (hsCRP, IL-6, IL-17 and TNF-α). In PCOS females, there is an alteration of various hormone levels in the body. Female sex steroid hormones play a key role in periodontal disease progression and periodontal and implant wound healing. Human gingiva has the capacity to metabolize hormones such as estrogen and progesterone. Moreover, gingival tissue exhibits receptors for such hormones and it is considered as a target organ for their direct action. These hormones might act on gingival cells by changing the effectiveness of the epithelial barrier to bacterial injury or by affecting the collagen maintenance and repair. To avoid periodontal implications as these hormonal changes can worsen the vulnerability to plaque-induced periodontal disease. So, present study is going to conduct in females with PCOS and periodontitis at different age groups like adolescent and adult age groups. AIM - Assessment of impact of polycystic ovary syndrome on periodontal status of women of adolescent and adult age groups.

NCT ID: NCT05101434 Completed - Stroke Clinical Trials

Gingivitis and Periodontitis as a Risk Factor for Stroke

Start date: January 10, 2021
Phase:
Study type: Observational [Patient Registry]

Periodontitis and gingivitis are one of the most infectious diseases in humans. Several studies have been carried out on the dependence of periodontitis and stroke. The aim of this study was to investigate gingivitis and periodontitis as risk factors for stroke in the Pakistani population.

NCT ID: NCT05089214 Recruiting - Periodontitis Clinical Trials

ONE-1 Oral graNd Est 1

ONE
Start date: June 16, 2022
Phase: N/A
Study type: Interventional

This study is about the assessment of two oral telemedecine tools compared to an intra oral clinical examination used as a reference among elderly persons living in nursing home. Our hyposthesis is that the diagnostic performance of the two devices will be similar. The main goal of the study is to assess the performances of two intra-oral cameras compared to an intra oral clinical examination to detect at least one decayed tooth. The secondary objectives of this study are : At patient's level: 1. To assess the performances of two intra-oral cameras types compared to an intra oral clinical examination for detecting each of the following conditions: (i) at least one filled tooth, (ii) at least one missing tooth, (iii) gingivitis, (iv) an abscess, (v) dental plaque and (vi) calculous 2. To assess the concordance between each intra oral cameras and the intra oral clinical examination in the evaluation of the number (i) of decayed teeth, (ii) filled teeth and (iii) missing tooth 3. From video acquisitions of each intra oral cameras, to assess the inter-observer concordance for the diagnostic of each dental pathologies (presence of at least one decayed tooth, filled or missing) and periodontal (presence of gingivitis, abscess, dental plaque or scale) 4. From video acquisitions of each intra oral cameras, to assess the inter-observer agreement of the number of teeth: (i) decayed, (ii) filled and (ii) missing At tooth level : 5. To assess the performances of two intra-oral cameras types compared to an intra oral clinical examination for detecting each of the following conditions: (i) a cavity, (ii) a filled tooth and (iii) missing tooth In all patients : 6. To assess patient's feelings about the use of each intra oral cameras 7. To compare the time required for video acquisitions between each of intra oral cameras For patients with dental or periodontal pathologies observed during the intra oral examination: 8 To assess, 2 months after initial evaluation, the proportion of patients attended dental or periodontal care and for which an appointment with a dentist has been scheduled

NCT ID: NCT05079204 Not yet recruiting - Periodontitis Clinical Trials

Intraoral Scanners as a Motivation Method for Oral Hygiene Instruction

Perio3D
Start date: May 2023
Phase: N/A
Study type: Interventional

Periodontal diseases are highly prevalent inflammatory diseases. These diseases are mostly due to the development and the maturation of bacterial plaque which lead to local inflammation. Individuals can develop severe attachment loss which could lead to dental loss. To prevent them, individual plaque removal procedures self-performed by the patient by tooth brushing or interdental brushes or made by professional care (scaling), are known to improve periodontal health, and thus to prevent periodontal diseases. Moreover, oral hygiene is a major factor to increase increasing the outcomes when treatments are needed. However, patients' compliance in oral health program is one of the major limits to periodontal therapeutics. In this study, the investigators evaluate the effectiveness of 3D intra-oral camera compared with conventional oral hygiene instructions, to improve oral health motivation.

NCT ID: NCT05073393 Completed - Dental Caries Clinical Trials

Effect of Probiotics on Oral Homeostasis During Sugar Stress

Start date: November 3, 2021
Phase: N/A
Study type: Interventional

The present study is a double-blinded randomized clinical trial with a duration of 28 days.

NCT ID: NCT05073107 Completed - Periodontitis Clinical Trials

The Effect of A Dental Application to Promote Self-Administered Plaque Control: A RCT

Start date: December 6, 2021
Phase: N/A
Study type: Interventional

Randomized Controlled Trial: to investigate the feasibility of the usage of a mobile dental application in the self-administration of plaque control in a two (2) parallel arm study with 52 subjects (n = 52). The study will take place over 2 visits (within 35 days): Visit 1 and 2. Prospective Open Cohort Study: Patients referred to the Periodontology Department will be invited to participate in the study during the Oral Hygiene Phase. Routine clinical indices will be recorded at Visit 1 and Visit 2 before active non-surgical periodontal treatment commences.

NCT ID: NCT05070507 Completed - Gingivitis Clinical Trials

Effect of an Enzyme-containing Lozenge on Dental Biofilm in Healthy Individuals.

Start date: January 8, 2021
Phase: N/A
Study type: Interventional

The purpose of the study is to assess the effect of an enzyme containing lozenge on dental plaque accumulation in healthy adults.