Gingival Recession Clinical Trial
Official title:
The Influence of Non-Carious Cervical Lesions on Root Coverage by Means of Coronally Advanced Flap and a Connective Tissue Graft: A Prospective Cohort Study
The goal of this prospective cohort study is to evaluate the effect of non-carious cervical lesions (NCCLs) on the outcome of root coverage therapy. The main question it aims to answer is: In gingival recessions associated with NCCLs, characterized by an undetectable cemento-enamel junction (CEJ), reconstruction of the CEJ with a cervical composite restoration, prior to root coverage surgery by means of a coronally advanced flap combined with a connective tissue graft (CAF+CTG), provides similar clinical and patient-reported outcomes, as compared to the treatment of gingival recessions associated with NCCLs, characterized by a visible CEJ, with root coverage surgery only, by means of a CAF+CTG. In NCCLs where the CEJ is undetectable (B-type defect), the CEJ will be reconstructed before surgery with a cervical composite restoration mimicking the anatomic features of the contralateral, homologous tooth. CAF+CTG treatment will be performed in all cases. Participants will be assessed at 6 weeks, 3 months, and 6 months to evaluate clinical, volumetric, and patient-centred outcomes.
In this investigation, a prospective cohort study, several key outcomes will be assessed. First, we seek to determine whether restoring the cementoenamel junction (CEJ) in Class B GRs before root coverage therapy yields comparable clinical and volumetric outcomes to Class A GRs with detectable CEJ. In addition, the influence of the CEJ restoration on dentin sensitivity and aesthetic satisfaction of the patient will be investigated. To our knowledge, it will be the first clinical study to use Pini Prato et al.'s surface discrepancy classification as a decision-making tool to guide periodontal-restorative procedures. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04462237 -
Recombinant Human Platelet-derived Growth Factor in Combination With Collagen Matrix
|
N/A | |
| Enrolling by invitation |
NCT05591326 -
The Effect of Using Injectable Platelet-rich Fibrin on Root Surface Closure in Patients With Gingival Recession.
|
N/A | |
| Completed |
NCT06118177 -
Ultrasonographic Assessment of Palatal Wound Healing
|
||
| Not yet recruiting |
NCT06044870 -
Clinical Evaluation of the Modified Laterally Stretched Technique (RT2) Gingival Recession vs Tunneling With CT Grafting
|
Phase 2 | |
| Recruiting |
NCT02995070 -
Low Intensity Laser Therapy in Connective Tissue Graft for Root Coverage in Smokers
|
N/A | |
| Completed |
NCT03204565 -
Effectiveness of Adjunctive Hyaluronic Acid Application in Coronally Advanced Flap in Single Gingival Recession Sites
|
N/A | |
| Completed |
NCT01440426 -
Connective Tissue Graft Versus Mucograft Collagen Matrix for Coverage of Multiple Gingival Recession Defects
|
Phase 4 | |
| Completed |
NCT02129504 -
Two Techniques for Root Coverage With a Xenogeneic Collagen Matrix
|
N/A | |
| Completed |
NCT01547962 -
A Pilot Clinical Trial of Gintuit (TM)in Establishing a Functional Zone of Attached Gingiva
|
N/A | |
| Completed |
NCT04043039 -
Platelet Rich Fibrin in the Treatment of Full Thickness Palatal Wounds
|
N/A | |
| Recruiting |
NCT04920136 -
Gain of Keratinized Mucosa Around Teeth and Dental Implants Using a Combination of Strip Gingival Graft and Acellular Dermal Matrix
|
N/A | |
| Active, not recruiting |
NCT03570333 -
Progenitor Potential of Mesenchymal Stem Cells in Palatal Tissue Harvested From Molar and Premolar Sites
|
N/A | |
| Recruiting |
NCT05045586 -
MCAT With HA and sCTG Compared With sCTG Alone for Treatment of Multiple Gingival Recession: Clinical Trial
|
N/A | |
| Active, not recruiting |
NCT05101642 -
Guided Creeping Technique (GCT) in Treating Gingival Recession
|
N/A | |
| Completed |
NCT04813302 -
Influence of Anatomical Factors Upon Root Coverage
|
N/A | |
| Recruiting |
NCT06006780 -
Porcine Acellular Dermal Matrix for the Treatment of Localized Gingival Recessions A Multicenter Randomized Clinical Trial.
|
N/A | |
| Recruiting |
NCT06044727 -
MINST Versus Conventional Subgingival Instrumentation In RT1 Gingival Recession
|
N/A | |
| Enrolling by invitation |
NCT06330662 -
Effectiveness of Hyaluronic Acid on Multiple Adjacent Gingival Recessions Using a Coronally Advanced Flap
|
N/A | |
| Not yet recruiting |
NCT05472233 -
Effect of Suturing Protocols on Coronally Advanced Flap for Root Coverage Outcomes
|
N/A | |
| Recruiting |
NCT05563428 -
Free Gingival Graft Versus Connective Tissue Graft
|
N/A |