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NCT04434794 Clinical Trial

Treatment of Gingival Recession Using Mesenchymal Stem Cells

Gingival Recession Clinical Trial

Official title:
Treatment of Gingival Recession Using Autologous Adipose-derived Mesenchymal Stem Cells

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04434794
Other study ID # IBCE_MSC(GR2)
Secondary ID
Status Completed
Phase Phase 1/Phase 2
First received
Last updated
Start date January 1, 2018
Est. completion date December 31, 2019

Study information
Verified date June 2020
Source Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Treatment of patients with gingival recession by injection of autologous adipose-derived mesenchymal stem cells mixed with collagen gel

Description:

Treatment of patients with gingival recession by injection of autologous adipose-derived mesenchymal stem cells mixed with collagen gel (1×106cells/0.2 ml). The volume of the mixture is divided into 4 equal injections in the gingival region of one tooth (one place injection volume is 0.05 ml of mixture).

Recruitment information / eligibility
Status Completed
Enrollment 27
Est. completion date December 31, 2019
Est. primary completion date December 31, 2019
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

-gingival recession

Exclusion Criteria:

- pregnancy

- breast-feeding

- acute and chronic infectious diseases: HIV, viral hepatitis, tuberculosis

- mental disorders

Study Design

Related Conditions & MeSH terms

Intervention

Biological:
• mesenchymal stem cells
autologous mesenchymal stem cells
Other:
• standard treatment
standard treatment according to clinical protocols

Locations
Country Name City State
Belarus Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus Minsk

Sponsors (2)
Lead Sponsor Collaborator
Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus Belarusian Medical Academy of Post-Graduate Education

Country where clinical trial is conducted

Belarus, 

Outcome
Type Measure Description Time frame Safety issue
Primary number of patients cured number of patients cured 1 month
See also
  Status Clinical Trial Phase
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Enrolling by invitation NCT05591326 - The Effect of Using Injectable Platelet-rich Fibrin on Root Surface Closure in Patients With Gingival Recession. N/A
Completed NCT06118177 - Ultrasonographic Assessment of Palatal Wound Healing
Not yet recruiting NCT06044870 - Clinical Evaluation of the Modified Laterally Stretched Technique (RT2) Gingival Recession vs Tunneling With CT Grafting Phase 2
Recruiting NCT02995070 - Low Intensity Laser Therapy in Connective Tissue Graft for Root Coverage in Smokers N/A
Completed NCT03204565 - Effectiveness of Adjunctive Hyaluronic Acid Application in Coronally Advanced Flap in Single Gingival Recession Sites N/A
Completed NCT01440426 - Connective Tissue Graft Versus Mucograft Collagen Matrix for Coverage of Multiple Gingival Recession Defects Phase 4
Completed NCT02129504 - Two Techniques for Root Coverage With a Xenogeneic Collagen Matrix N/A
Completed NCT01547962 - A Pilot Clinical Trial of Gintuit (TM)in Establishing a Functional Zone of Attached Gingiva N/A
Completed NCT04043039 - Platelet Rich Fibrin in the Treatment of Full Thickness Palatal Wounds N/A
Recruiting NCT04920136 - Gain of Keratinized Mucosa Around Teeth and Dental Implants Using a Combination of Strip Gingival Graft and Acellular Dermal Matrix N/A
Active, not recruiting NCT03570333 - Progenitor Potential of Mesenchymal Stem Cells in Palatal Tissue Harvested From Molar and Premolar Sites N/A
Recruiting NCT05045586 - MCAT With HA and sCTG Compared With sCTG Alone for Treatment of Multiple Gingival Recession: Clinical Trial N/A
Active, not recruiting NCT05101642 - Guided Creeping Technique (GCT) in Treating Gingival Recession N/A
Completed NCT04813302 - Influence of Anatomical Factors Upon Root Coverage N/A
Recruiting NCT06006780 - Porcine Acellular Dermal Matrix for the Treatment of Localized Gingival Recessions A Multicenter Randomized Clinical Trial. N/A
Recruiting NCT06044727 - MINST Versus Conventional Subgingival Instrumentation In RT1 Gingival Recession N/A
Enrolling by invitation NCT06330662 - Effectiveness of Hyaluronic Acid on Multiple Adjacent Gingival Recessions Using a Coronally Advanced Flap N/A
Not yet recruiting NCT05472233 - Effect of Suturing Protocols on Coronally Advanced Flap for Root Coverage Outcomes N/A
Recruiting NCT05563428 - Free Gingival Graft Versus Connective Tissue Graft N/A