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NCT03871218 Clinical Trial

Effect of Hyaluronic-acid on the Healing After Free Gingival Graft

Gingival Recession Clinical Trial

Official title:
Evaluation of the Effect of Hyaluronic Acid Application on the Healing of the Donor and Recipient Sites After Free Gingival Graft With Laser Doppler Flowmetry

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03871218
Other study ID # 19.04.2017 08/14
Secondary ID
Status Completed
Phase Phase 2
First received
Last updated
Start date April 1, 2017
Est. completion date December 1, 2018

Study information
Verified date April 2017
Source Gazi University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study evaluated the effect of topical hyaluronic acid (HA) application on free gingival graft (FGG) donor and recipient sites during the early wound healing period with laser Doppler flowmetry (LDF) and to investigate the effect of HA application on the dimensional change of the graft.Participants were randomly classified into the test group (TG) and control group (CG). HA was applied to both donor and recipient sites in 20 patients who formed the TG, whereas HA was not applied to the 20 patients who formed the CG.

Description:

The healing of a transplanted tissue depends on the formation of blood support between the donor and recipient sites.

Hyaluronic acid (HA) is a biomaterial that creates a favorable environment for wound healing due to its unique hydroscopic and viscoelastic properties, and it is important for wound healing activities.HA induces angiogenesis following degradation and improves the wound healing environment.HA supports a mechanism that induces proliferation of capillaries, and components produced after HA degradation increase vascularization.Laser Doppler flowmetry (LDF) technique is frequently used in the field of plastic surgery for monitoring microvascular blood flow to detect insufficient circulation in the skin transplants and flaps in the early period and to thereby prevent and predict possible surgical complications.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date December 1, 2018
Est. primary completion date April 1, 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 25 Years to 45 Years
Eligibility Inclusion Criteria:

- Clinically diagnosed inadequate attached gingiva

Exclusion Criteria:

- Smoking

Study Design

Related Conditions & MeSH terms

Intervention

Biological:
• Hyaluronic acid group
Applicaton of topical Hyaluronic acid

Locations
Country Name City State
Turkey Gazi University Faculty of Dentistry Department of Periodontology Ankara Çankaya

Sponsors (1)
Lead Sponsor Collaborator
Gazi University

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary blood perfusion value in the recipient bed The comparison of blood perfusion value in the recipient bed between the TG and CG on day 4 on day 4
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