Gingival Recession Clinical Trial
Official title:
Effectiveness of Adjunctive Hyaluronic Acid Application in Coronally Advanced Flap in Miller Class I Single Gingival Recession Sites
The purpose of this randomized controlled clinical trial (RCT) is to determine the efficacy
hyaluronic acid (HA) in combination with the coronally advanced flap (CAF) for the treatment
of single gingival recession site.
The hypothesis is that HA will result in improved the clinical outcomes and will reduce the
pos-operative morbidity
Gingival recession is a common clinical finding in patients with high standards of oral
hygiene and can be found in more than 90% of patients. Buccal exposure of roots with
aesthetic impairments and dentinal hypersensitivity The ultimate goal of root coverage
procedures is the complete coverage of the recession defect with an aesthetic appearance
comparable to adjacent healthy soft tissues in combination with physiological probing pocket
depths.Several surgical techniques have already provided good results and have been shown to
attain root coverage at individual recession sites these different methods.To date,
connective tissue grafts (CTG) and enamel matrix derivatives (EMD) in conjunction with a
coronally advanced flap (CAF) have been shown to provide the highest probability of
obtaining complete root coverage (CRC) in Miller class I and II single gingival recession as
compared to CAF alone.
Hyaluronic acid (HA) is a major component of the extracellular matrix in almost all tissues.
The primary role of HA is to bind water and to permit the transportation of key metabolites
and therefore to maintain the structural and homeostatic integrity of these tissues.
In vitro and animal studies have demonstrated that hyaluronic acid have many properties that
are essential for tissue regeneration and wound healing.
However, to the best of our knowledge, there have been limited clinical application studies
in the field of root coverage procedures performed and still no consistent published data
with longer follow-ups on the usage of HA are available.
Therefore, the aim of this randomized controlled clinical trial (RCT) was to evaluate the
potential benefit of the adjunctive use of HA in combination with a coronally advanced flap
(CAF) and to compare the outcomes with CAF alone, when treating single Miller Class I
gingival recessions.
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