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Gingival Recession, Localized clinical trials

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NCT ID: NCT06432439 Not yet recruiting - Clinical trials for Gingival Recession, Localized

Impact of Microneedling on Coverage of RT1 Gingival Recession in Thin Phenotype.

Start date: June 1, 2024
Phase: N/A
Study type: Interventional

Gingival Recession (GR) is a common finding in among adults, regardless of the oral hygiene levels. When it is associated with esthetic impairment, dentin hypersensitivity, root caries, surgical treatment is indicated. Mid-buccal Gingival Recessions are an extremely prevalent condition and have root coverage potential through periodontal plastic surgery procedures. A flap thickness of > 0.8 mm results in a covered root surface of 100%, whereas a flap thickness of < 0.8 mm results in partial root coverage in Coronally Advanced Flap (CAF)procedure. The present study aims to increase the gingival thickness by microneedling procedures to enhance root coverage by CAF procedures in thin gingival phenotype.

NCT ID: NCT06404762 Recruiting - Clinical trials for Gingival Recession, Localized

Tuberosity Versus Palatal Connective Tissue Graft on the Treatment of Single Maxillary Recession-type Defects

Start date: July 1, 2023
Phase: N/A
Study type: Interventional

The goal of this randomized clinical study is to assess the root coverage outcomes and patient morbidity following the treatment of single maxillary recession-type defects using a coronally advanced flap (CAF) combined with a subepithelial connective tissue graft (SCTG) harvested from the maxillary tuberosity (MT) versus lateral palate (LP). The secondary objective is to evaluate the histological characteristics of graft compositions harvested from the different regions (MT versus LP). Therefore, the following questions related to the study are raised: - Do SCTGs harvested from MT (tSCTG) and LP (pSCTG) exhibit similar root coverage outcomes in the treatment of single maxillary recession-type defects using CAF? - What are the histological characteristics of tSCTG and pSCTG? A total of 30 patients who have been referred to the Gazi University Department of Periodontology will be randomly assigned to receive tSCTG or pSCTG in combination with CAF. Clinical measurements will be recorded at baseline, 1, 3, 6, and 12 months after surgeries. Immediately after interventions; a questionnaire evaluating post-operative pain, discomfort, sensitivity, and bleeding will be given to the patients. The amount of non-steroid anti-inflammatory drugs used will be recorded at 1, 2, 3, 7, 14 and 28 days after surgery. Descriptive morphologic analysis of the grafts will be assessed in terms of the presence of inflammatory cells, connective tissue cellularity, vascularization, adipose tissue, and collagen structure.

NCT ID: NCT06388447 Enrolling by invitation - Clinical trials for Gingival Recession, Localized

Reconstruction of Deficient Interdental Papilla Using Stem Cells vs Physiological Saline

Start date: December 1, 2023
Phase: Phase 4
Study type: Interventional

The goal of this study is to assess the reconstruction of interdental papilla following the injection of UC-MSCs or physiological saline in patients with interdental papilla deficiency. Participants will be randomised into 2 groups (intervention vs placebo) to receive the treatment.

NCT ID: NCT06373783 Completed - Clinical trials for Gingival Recession, Localized

Ultrasonographic Evaluation of the Connective Tissue Grafts Obtained With Two Different Methods in Root Coverage

Start date: June 15, 2023
Phase: N/A
Study type: Interventional

Gingival recession is a clinical problem that increases with age and affects patient comfort. It is defined as the displacement of the gingival margin to a more apical position of the cementum-enamel border of the tooth. Coronally advanced flap (CAF) or tunnel technique (TUN) with subepithelial connective tissue procedures have been reported to be the most predictable methods of single gingival recession treatments. The ultimate goal of these plastic periodontal surgical procedures is to close the exposed root surface and achieve optimum aesthetic results. The main indications for root coverage (RC) procedures are aesthetic concern, root hypersensitivity, prevention of cervical abrasion and root caries, improvement of restorative results, and facilitation of plaque control. The use of a subepithelial connective tissue graft (SCGT) combined with a coronally positioned flap is considered the gold standard by many authors for single gingival recession treatments. De-epithelialization of free gingival grafts (DGG) has been proposed, especially when palatal tissue thickness is insufficient (≤2.5 mm) and larger graft size in the apico-coronal or mesio-distal directions is required. In this technique, the graft of the required width and length is separated from the lateral side of the palate, and then the 0.3-0.5 mm thick epithelial layer of the resulting graft is cut from the connective tissue layer. Ultrasonography (USG) is based on the principle of recording data obtained as a result of ultrasound waves sent with the help of a probe hitting and reflecting on substances of different densities. This technique is widely used in medical practice. In dentistry, the USG method is used to measure the alveolar bone level and the dimensions of the periodontium to evaluate the gingival thickness. It also has functions to evaluate color power and color speed, as well as blood flow. The study hypothesizes that combining SCGT and DGG with a coronally positioned flap could yield different clinical outcomes in patients with a single buccal gingival recession. This study aims to compare the clinical success of connective tissue grafts obtained by two different surgical methods in covering the root surface with ultrasonography (USG).

NCT ID: NCT06228534 Not yet recruiting - Gingival Recession Clinical Trials

Root Coverage With Tunneling Technique With Connective Tissue Versus Coronal Advancement Flap Technique.

Start date: March 20, 2024
Phase: N/A
Study type: Interventional

This is a randomized triple-blind clinical trial. This comparative clinical study investigates the efficacy of root coverage using two periodontal techniques: the tunneling technique and the coronal advancement technique. The objective is to evaluate and compare the clinical, esthetic and patient perception outcomes after undergoing each procedure. Participants with specific gingival recessions will be included, and follow-up will be performed to measure root coverage, keratinized tissue gain and other relevant parameters. In addition, a detailed analysis of the morbidity associated with each technique will be performed. This study aims to provide valuable information to guide oral health professionals in choosing the most appropriate technique for the treatment of gingival recessions.

NCT ID: NCT06197893 Completed - Clinical trials for Gingival Recession, Localized

Modified Sling and Conventional Suture Techniques in Free Gingival Graft Operations

Start date: March 15, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the effects of conventional suture (CS) and modified sling suture (MSS) techniques, applied in free gingival graft (FGG) surgery using gingival unit graft (GUG) and conventional graft (CG) techniques, on clinical parameters and graft dimensions.

NCT ID: NCT06065774 Enrolling by invitation - Clinical trials for Gingival Recession, Localized

Comparing Two Different Tunneling Technique for Gingival Recession Treatment Using Two Different Matertial

Start date: July 17, 2022
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to compare two different tunneling surgical technique in treatment of gingival recession using two different materials. Participants will be divided into four groups according to the treatments they'll be given.

NCT ID: NCT06030947 Not yet recruiting - Clinical trials for Gingival Recession, Localized

Effectiveness of Meshed Connective Tissue Graft for Treatment of Multiple Adjacent Gingival Recession Defects

Start date: June 1, 2024
Phase: N/A
Study type: Interventional

The objective of this project is to evaluate short-term and 1-year outcomes of treatment of multiple adjacent gingival recession defects (MAGRD) using the coronally advanced flap (CAF) with either conventional CTG (control group) or meshed CTG (mesh-CTG) (test group).

NCT ID: NCT06000228 Recruiting - Clinical trials for Gingival Recession, Localized

Effect of Vestibular Depth on Predictability of Miller Class III/ RT2 Gingival Recession Coverage

Start date: September 15, 2023
Phase: N/A
Study type: Interventional

Aim of this study is to assess the influence of vestibular depth on root coverage in Miller class III/ Cairo RT2 gingival recession when treated with minimally invasive technique using connective tissue graft.

NCT ID: NCT05990049 Recruiting - Pain, Postoperative Clinical Trials

Hyaluronic Acid and Free Gingival Graft Healing

Start date: March 1, 2023
Phase: Phase 3
Study type: Interventional

This study aims to evaluate the impact of locally applied hyaluronic acid on free gingival graft wound bed healing and palatal donor site wound healing. Forty subjects will be randomly divided in two separate groups. Test group will be treated with hyaluronic acid during the procedure and the control group without. Periodontal parameters and other clinical measurements will be taken on baseline, 7 days postoperative, 14 days postoperative, 1 month, 3 months and 6 months postoperative.