Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome

Gilles de la Tourette's Syndrome Clinical Trial

Official title:

Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00664300
• Other study ID #: CHU-0032
• Secondary ID: RBHP 2007 Jalenq
• Status: Completed
• Phase: N/A
• First received: April 21, 2008
• Last updated: January 18, 2011
• Start date: August 2007
• Est. completion date: October 2009

Study information

• Verified date: January 2011
• Source: University Hospital, Clermont-Ferrand
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Ministry of Health
• Study type: Observational

Clinical Trial Summary

Gilles de la Tourette's syndrome is a childhood onset inherited neuropsychiatric disorder characterised by the presence of both multiple motor tics and one or more vocal tics (noises), with psychiatric and/or behaviour disorders (such as obsessive compulsive behaviour…).

This disease is associated with an dopamine system imbalance which could be responsible of a specific trouble in the recognition in some facial expression. This has been already shown in Gilles de la Tourette patients with obsessive compulsive behaviour.

We hypothesise that patients with Gilles de la Tourette's syndrome present a dysfunction of voluntary and automatic treatment of emotional information.

The main purpose of this study is to show if patients with Gilles de la Tourette's syndrome present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).

Description:

20 patients with Gilles de la Tourette's syndrome compared to 20 healthy paired volunteers.

Study progress (patients):

Inclusion visit :

Psychiatric evaluation Psychological evaluation

Ophthalmic visit

Protocol :

Facial expression recognition test Lexical decision test

Study progress (healthy volunteers):

Psychiatric evaluation Ophthalmic visit Facial expression recognition test Lexical decision test

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: October 2009
• Est. primary completion date: October 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age : >18 years

• Patient with a Gilles de la Tourette 's syndrome such as defined in the DSMIV

• Stability of treatment >1 month

• Mini Mental State > 26

• Affiliation to social security

• Agreement of patients

Exclusion Criteria:

• Patients with cognitive disorders, dementia, mental retardation…

• Patients with serious neurological pathologies

• Patients with a vision contrast altered.

• Patients who do not understand the words associated with an emotion

• Pregnant women

• Person who participate to an other study

Study Design

N/A

Related Conditions & MeSH terms

• Gilles de la Tourette's Syndrome
• Syndrome
• Tourette Syndrome

Intervention

Behavioral:
• Facial expression recognition of emotion
Facial expression recognition test Lexical decision test

Locations

Country	Name	City	State
France	CHU	Clermont-Ferrand

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Clermont-Ferrand

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Facial expression recognition test		% of exact responses	Yes
Secondary	Lexical decision test		The time to respond	Yes