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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01466231
Other study ID # GCTSK002
Secondary ID
Status Completed
Phase Phase 2
First received October 31, 2011
Last updated January 11, 2016
Start date November 2011
Est. completion date June 2015

Study information

Verified date January 2016
Source National Cancer Institute, Slovakia
Contact n/a
Is FDA regulated No
Health authority Slovakia: State Institute for Drug Control
Study type Interventional

Clinical Trial Summary

Everolimus in refractory testicular germ cell cancer. Everolimus 10 mg /day/ is administered to the patient until progression, unacceptable toxicity, complete response or inability of the subject to comply with study requirements. Feasibility of surgical resection will be assessed after every 2 cycles of the treatment in patients with partial response.


Description:

Treatment Schedule: Everolimus will be administered at a dose of 10mg/day orally once a day. One cycle of therapy consists of 28 days.

Estimated duration of treatment: Until progression, unacceptable toxicity, complete response or inability of the subject to comply with study requirements.

Feasibility of surgical resection will be assessed after every 2 cycles of the treatment in patients with partial response.


Recruitment information / eligibility

Status Completed
Enrollment 15
Est. completion date June 2015
Est. primary completion date June 2015
Accepts healthy volunteers No
Gender Male
Age group 18 Years and older
Eligibility Inclusion Criteria:

1. Signed written informed consent

2. Men aged 18 years or older

3. ECOG performance status: 0-2,

4. Histological confirmed extracranial primary germ cell cancer, seminoma, or nonseminoma

5. Rising serum markers (i.e., alpha-fetoprotein and human chorionic gonadotropin) on sequential measurement or biopsy-proven unresectable germ cell cancer

6. Refractory GCTs e.g. patients relapsing after high-dose chemotherapy or for patients non fit enough for high-dose chemotherapy

7. Primary mediastinal GCTs in first relapse

8. Patient's disease must not be amenable to cure with either surgery or chemotherapy in the opinion of investigator,

9. Measurable disease radiological

10. Adequate hematologic function defined by WBC > 4000/mm3, platelet count > 100 000/mm3 and hemoglobin level > 9g/dl.

11. Adequate liver function defined by a total bilirubin level < 1.5 ULN, and ALT, AST < 2,5 ULN and adequate renal function defined by serum creatinine = 1.5 x ULN.

12. At least 2 weeks must have elapsed since the last radiotherapy and/or chemotherapy before study entry,

13. At least 4 weeks must have elapsed since the last major surgery

14. Complete recovery from prior surgery, and/or reduction of all adverse events from previous systemic therapy or radiotherapy to grade 1,

15. Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule, -

Exclusion Criteria:

1. Patients who do not fit inclusion criteria,

2. Other prior malignancy except successfully treated non melanoma skin cancer

3. Prior treatment with mTOR inhibitor

4. No other concurrent approved or investigational anticancer treatment, including surgery, radiotherapy, chemotherapy, biologic-response modifiers, hormone therapy, or immunotherapy

5. Female patients,

6. Patients infected by the Human Immunodeficiency Virus (HIV),

7. Patients with other severe acute or chronic medical condition, or laboratory abnormality that would impair, in the judgment of investigator, excess risk associated with study treatment, or which, in judgment of the investigator, would make the patient inappropriate for entry into this study,

8. Inability of oral intake, or drug absorption (e.g. malabsorption syndrome)

9. Hypersensitivity to any compound of the drug,

10. Sexually active men not using effective birth control if their partners are women of child-bearing potential.

11. Patients with active CNS metastasis

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


Intervention

Drug:
Everolimus
Tablets p.o. 10 mg daily until progression, unacceptable toxicity, complete response or inability of the subject to comply with study requirements.

Locations

Country Name City State
Slovakia National Cancer Institute Bratislava

Sponsors (1)

Lead Sponsor Collaborator
National Cancer Institute, Slovakia

Country where clinical trial is conducted

Slovakia, 

Outcome

Type Measure Description Time frame Safety issue
Primary Response rate according RECIST criteria version 1.1 36 month No
Secondary Favorable response rate complete response with chemotherapy and/or surgery, partial response marker negative. 36 month No
Secondary Clinical benefit rate (complete and partial response and stable disease > 6 months) 36 month No
Secondary Progression-free survival expressed as median and as 12-weeks post-treatment initiation continuous progression-free survival rate 36 month No
Secondary Toxicity 36 month Yes
Secondary Frequency of grade III and IV adverse events 36 month Yes
Secondary Association between clinical outcome and biomarkers 36 month No
Secondary Serum tumor markers response >90% decline of AFP and/or HCG 36 month No
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