Genetic Predisposition to Disease Clinical Trial
Official title:
Clinical Application of the European Horizon 2020 Research Project "BRIDGES" - Study of the Psychological Impact of Breast Cancer Risk Communication in Cancer Genetics Based on the Personalized Estimation of the BOADICEA V5/PLUS Model
Study of the psychological impact of breast cancer risk communication in Cancer Genetics based on the personalized estimation of the BOADICEA V5/PLUS model ("Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm-version 5 or PLUS").
The new BC gene testing and risk estimation using BOADICEA V5/PLUS model imply an increased complexity of communication during the cancer genetic consultation. It will be proposed to women referred to genetic counselling in the participating Cancer Genetic Clinics . New qualitative (moderate risks, secondary results) and quantitative results (variation in the degree of cancer risk identified for the counselee and family members) and thus a personalized breast cancer risk may be obtained. How this complexity affects counselees' psychological reactions is not known. It is primarily aimed at comparing psychosocial needs and distress in healthy women (unaffected with BC) at high risk of breast or ovarian cancer undergoing genetic testing based on an enriched gene panel (index case gene panel plus PRS) at Curie Institute in France and at the University Hospital in Cologne, Germany. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05020574 -
Microbiome and Association With Implant Infections
|
Phase 2 | |
| Recruiting |
NCT06057181 -
Helix Research Network
|
||
| Recruiting |
NCT04390269 -
Immunogenetics Predictors With COVID-19
|
||
| Recruiting |
NCT04427163 -
Assesment of Multiomics Profiles in Health and Disease.
|
||
| Completed |
NCT03597659 -
PheWAS of a Polygenic Predictor of Thyroid Function
|
||
| Recruiting |
NCT06399666 -
Impact of Inflammatory Indexes and Gene Scores in Prediction of Atrial Fibrillation Recurrence Following Electrical Cardioversion
|
||
| Active, not recruiting |
NCT04634032 -
Gene Expression and DNA Variation Analysis of Sacs to Identify the Pathophysiology of Indirect Inguinal Hernia
|
||
| Recruiting |
NCT04600544 -
Russian Disc Degeneration Study
|
||
| Not yet recruiting |
NCT04788927 -
Development of a Predictive Model for the Risk of Metastatic Disease in PPGLs, a Retrospective Cohort Study
|
||
| Not yet recruiting |
NCT03234140 -
Constitutional Genetics in Follicular Lymphoma
|
N/A | |
| Completed |
NCT01973075 -
Genetic Etiology in Premature Ovarian Insufficiency
|
N/A | |
| Completed |
NCT00555503 -
Registry of Mastectomy for Breast Cancer Risk Reduction
|
N/A | |
| Active, not recruiting |
NCT05524909 -
Full-scale Intervention Study: Genetic Risk Communication and Wearables
|
N/A | |
| Suspended |
NCT04151368 -
Surgical and Patient Reported Outcomes of Robotic Nipple-Sparing Mastectomy
|
N/A | |
| Completed |
NCT02422511 -
Genomic Sequencing for Childhood Risk and Newborn Illness
|
N/A | |
| Completed |
NCT00677495 -
Gluten-free Diet in Gluten-genetically Predisposed Subjects
|
N/A | |
| Recruiting |
NCT05759143 -
Enhancing Information Management for Young Adults After Genetic Cancer Risk Testing
|
N/A | |
| Enrolling by invitation |
NCT05721326 -
Sequential EHR Based Interventions to Increase Genetic Testing for Breast and Ovarian Cancer Predisposition
|
N/A | |
| Active, not recruiting |
NCT05685810 -
Genetic Determinants of Kidney Disease in People of African Ancestry With HIV
|
||
| Recruiting |
NCT04903782 -
Cancer Predisposition Testing by Family-based Whole-genome Sequencing (WGS) in Every Child With Newly Diagnosed Cancer
|