Natriuretic Effect of Amiloride in Relation to the Alpha Adducin Gene (ADD-AMI) RS4961 Variant — ADD-AMI  

Genetic Hypertension Clinical Trial

Official title: Natriruetic Effect of Amiloride in Relation to the Alpha Adducin Gene (ADD-AMI) RS4961 Variant

Status Completed

Clinical Trial Summary

The study is a non-pharmacological interventional, single-center, national, non-randomised, comparative and open label.

Clinical Trial Description

The study is carried out to evaluate primarily the difference in the activity of the renal transporter ENaC (through dosage of sodium) through its inhibition with a single dose of Amiloride in hypertensive patients characterized by the polymorphism of alpha Adducin rs496. It's also aimed to see the difference in potassium and the change in systolic and diastolic blood pressure after amiloride administration ;

Related Conditions & MeSH terms

• Genetic Hypertension
• Hypertension

• NCT number: NCT06416735
• Study type: Interventional
• Source: Ospedale San Raffaele
• Status: Completed
• Phase: Phase 3
• Start date: September 28, 2018
• Completion date: July 20, 2020