Phase 1 Study of ELX-02 in Healthy Adults

Status Completed

Clinical Trial Summary

Phase 1 Single Ascending Dose Study in Normal Healthy Volunteers

Clinical Trial Description

This is a study in humans of ELX-02, an advanced synthetic aminoglycoside optimized as a translational read-through drug (TRID) for the treatment of genetic conditions caused by nonsense mutations. This is a classical Phase 1a study designed as a randomized, double-blinded, placebo-controlled, single dose escalation to evaluate the safety, tolerability and pharmacokinetics of ELX-02 in healthy adult volunteers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03292302
Study type	Interventional
Source	Eloxx Pharmaceuticals, Inc.
Contact
Status	Completed
Phase	Phase 1
Start date	September 26, 2017
Completion date	December 15, 2017

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT03548779` - North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2	N/A
Withdrawn	`NCT03658382` - Virtual Visits for Results Disclosure	N/A
Recruiting	`NCT02266615` - Biobank Clinical Genetics Maastricht (KG01)
Recruiting	`NCT02450851` - Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network
Recruiting	`NCT05472714` - Educational Video for Genetic Testing	N/A
Recruiting	`NCT04285814` - Technology Development for Noninvasive Prenatal Genetic Diagnosis Using Whole Fetal Cells From Maternal Peripheral Blood
Completed	`NCT05443113` - Young Pectus Excavatum Patients and Genetic Defects
Completed	`NCT05655741` - Modified Delphi for Genomic Bereavement Care
Completed	`NCT03847909` - A Study to Evaluate DCR-PHXC in Children and Adults With Primary Hyperoxaluria Type 1 and Primary Hyperoxaluria Type 2	Phase 2
Completed	`NCT04584528` - Implementing an Individualized Pain Plan (IPP) for ED Treatment of VOE's in Sickle Cell Disease	N/A
Not yet recruiting	`NCT06048523` - Prospective Cohort Study of Neurogenetic Diseases	N/A
Completed	`NCT02225522` - Genomic Sequencing in Acutely Ill Neonates	N/A
Enrolling by invitation	`NCT06089954` - Penn Medicine Biobank Return of Results Program	N/A
Completed	`NCT03713333` - Implementing Digital Health in a Learning Health System	N/A
Completed	`NCT03309605` - Phase 1 Study of ELX-02 in Healthy Adult Subjects	Phase 1
Recruiting	`NCT05499091` - Functional Study to Indentify Genetic Etiology of Rare Diseases - ORIGIN	N/A
Completed	`NCT04556500` - Turkish Version of the Affordance in the Home Environment for Motor Development-Toddler (AHEMD-T)
Completed	`NCT04556487` - Turkish Affordances in the Home Environment for Motor Development-Infant Scale (AHEMD-IS)
Recruiting	`NCT02551081` - Genomic Sequencing and Personalized Treatment for Birth Defects in Neonatal Intensive Care Units
Active, not recruiting	`NCT05049967` - iKnow: A Prospective Study to Evaluate the Use of Multi-omics in Multi-System, Early Onset Disorders