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Clinical Trial Summary

The purpose of this observational study is discovering potential biomarkers to predict antidepressant treatment response in patients with major depressive disorder (MDD) while comparing the transcriptomic changes between patients with MDD and healthy controls as well as before and after antidepressant treatment. Eligible patients will be assessed at Week 1, Week 2, Week 4 and Week 8 while healthy normal volunteers will only be evaluated at baseline. Assessments will include the following: an interview about mental and physical health, a physical examination including drawing of venous blood samples and several psychiatric rating scales.


Clinical Trial Description

This study is focusing on evaluating the peripheral immune system of major depressive disorder (MDD) and the impact of antidepressants treatment. Single-cell RNA sequencing and single-cell VDJ sequencing will be performed on peripheral blood mononuclear cells to collect transcriptome information and immune repertoire of peripheral blood in patients with MDD. Bulk RNA sequencing and flow cytometry will be used to validate the clinical value of results. This is a biomarker study (antidepressants); treatment will be carried out according to physicians' orders. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06182722
Study type Observational [Patient Registry]
Source Shanghai Mental Health Center
Contact Huangfang Li
Phone +86-2134773128
Email lihuafang@smhc.org.cn
Status Recruiting
Phase
Start date March 13, 2024
Completion date December 2025

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