Clinical Trials Logo

Clinical Trial Summary

This study aims to understand the role of metabolic tissues in the changes of the metabolism of pregnant women and whether this contributes to some women developing metabolic diseases of pregnancy such as gestational diabetes (GDM) or intrahepatic cholestasis of pregnancy (ICP). Samples of adipose tissue will be taken when pregnant women are having caesarean section or laparoscopic procedures.


Clinical Trial Description

There is a gradual change in metabolism in pregnancy. This is characterised by a switch from normal levels of cholesterol, glucose and bile acids in early pregnancy to high levels of lipids, glucose and bile acids in late pregnancy. This is important to ensure that nutrients are provided for the growing fetus. However, it results in some women developing metabolic diseases of pregnancy, e.g. gestational diabetes mellitus (GDM) or intrahepatic cholestasis of pregnancy (ICP). This project aims to understand the role of metabolic tissues in the changes of the metabolism of pregnant women. The investigators are asking for permission to collect samples of adipose tissue (subcutaneous and visceral fat) when women are having surgical procedures. Specifically, the investigators would like to take small samples of fat at two time points: 1. When having a caesarean section (3rd trimester of pregnancy) 2. When having laparoscopic surgery for ectopic pregnancy (1st trimester of pregnancy) Samples will only be taken from women having surgery as part of their clinical care. The investigators are requesting permission to collect samples from women with metabolic diseases of pregnancy (GDM and ICP) and matched controls (women with uncomplicated pregnancy). The investigators will also want to collect blood samples. There is evidence from non-pregnant individuals (and from animal studies) that the adipose tissue in different parts of the body function in different ways. Subcutaneous fat is typically a fat storage tissue while visceral adipose tissue plays a role in metabolism of fat. The investigators' studies in mice suggest that these different fat stores function differently in pregnancy, and they may play a role in the metabolic changes that cause dyslipidaemia and susceptibility to diabetes mellitus. The investigators aim to identify where there are similar changes in function of adipose tissue in human pregnancy, and whether this contributes to the development of GDM and ICP. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02495987
Study type Observational
Source Imperial College London
Contact
Status Active, not recruiting
Phase
Start date March 2015
Completion date March 31, 2025

See also
  Status Clinical Trial Phase
Not yet recruiting NCT02838147 - Effect of a Continuous Glucose Monitoring on Maternal and Neonatal Outcomes in Gestational Diabetes Mellitus Phase 3
Enrolling by invitation NCT01762826 - Myo-inositol, D-chiro-inositol, and D-chiro/Myo-inositol in Gestational Diabetes N/A
Recruiting NCT04192422 - DiGESTnewborn Study
Not yet recruiting NCT02916667 - Chrono Nutrition (CN) Intervention Program in Gestational Diabetes Mellitus N/A
Terminated NCT04146909 - The Effect of Lactation on Insulin Sensitivity and Lipolysis in Women N/A
Completed NCT05355038 - Effect of Lifestyle Modification on Pregnancy Outcome for GDM N/A
Completed NCT03748576 - A Prospective Randomized Controlled Trial of Mobile Medical Used for Management of Pregnant Women N/A
Recruiting NCT04930276 - Diet-glucose-gut Microbiome Net in Women With GDM N/A
Active, not recruiting NCT04424238 - the Effect of Mobile Medical Used for the Standardized Management of Gestational Diabetes N/A
Active, not recruiting NCT04794283 - Antenatal Hand Milking for Pregnant Women With Diabetes'
Recruiting NCT05881616 - Study on Serum Metabolomics of GDM
Recruiting NCT06127823 - Effect of Intensive Nutrition Training, Education, and Support in Gestational Diabetes - The INTENSE-GDM TRIAL N/A
Recruiting NCT05204706 - The MalaYsian GestatiOnal Diabetes and Prevention of DiabetES Study N/A
Recruiting NCT05744856 - A Co-created Self-care and Informal Support Intervention Study Among Women With GDM in Vietnam N/A
Enrolling by invitation NCT05212519 - Correlation of Vitamin D Levels in Early Pregnancy With Gestational Diabetes and Pregnancy Outcomes
Recruiting NCT03589092 - Genetic Causes of Gestational Diabetes in the Emirati Population
Completed NCT03426228 - In Vitro Fertilization Impact on Metabolic Parameters
Recruiting NCT06125704 - Time to Move in Pregnancy Hyperglycemia N/A
Recruiting NCT03981328 - The Effectiveness of Rt-CGM to Improve Glycemic Control and Pregnancy Outcome in Patients With GDM N/A
Completed NCT03505541 - Adipokines Effect in Myometrial Contractility