Prodromal Parkinsonian Features in GBA1 Mutation Carriers

Status Recruiting

Clinical Trial Summary

Objective of the trial. To define a sub-population which is at increased risk of developing Parkinson, beyond the fact of carrying Gaucher; in this sub-population the investigators shall conduct a comprehensive evaluation that includes a variety of non-invasive tests, whose purpose is to evaluate the state of the pre- Parkinson's disease signs, signs which can appear, even twenty years before the appearance of the disease, and also to compare them to a group of diagnosed Gaucher patients and a group of healthy people who are not carriers of Gaucher disease. A group of those carriers will be available for trial or for treatment, if there will be a medicine for the prevention of the development of Parkinson, obtainable.

Clinical Trial Description

The carriers, the healthy people and the Gaucher patients will undergo a number of non-invasive tests, which test the pre-Parkinson signs. The tests are based on various sense tests, blood tests, measuring of blood pressure, lying and standing, ultra-sound of the brain and a neurological test (test of the nervous system and various questionnaires). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05253560
Study type	Observational
Source	Shaare Zedek Medical Center
Contact	Ari Zimran, MD
Phone	+972-509149149
Email	azimran@gmail.com
Status	Recruiting
Phase
Start date	May 16, 2017
Completion date	December 31, 2025

View Details

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