Gastrointestinal Neoplasms Clinical Trial
Official title:
Safety Study of Combining Ultrasound Microbubbles and Chemotherapy to Treat Malignant Neoplasms of Liver Metastases From Gastrointestinal Tumors and Pancreatic Carcinoma
Ultrasonic sonoporation can increase the release of chemotherapeutics, thus increasing the therapeutic effects. The main purpose is to identify the safety of combining ultrasonic microbubbles and chemotherapeutics to treat malignant neoplasms of hepatic metastases from alimentary system and pancreatic carcinoma.
Ultrasonic sonoporation can increase the release of chemotherapeutics, thus increasing the
therapeutic effects.
1. Main purpose
1. To identify the safety of combining ultrasonic microbubbles and chemotherapeutics
to treat malignant neoplasms of hepatic metastases from alimentary system and
pancreatic carcinoma.
2. To explore the largest mechanical index and ultrasonic treatment time which
patients can endure.
2. Secondary purpose
1. To observe tumor clinical benefit rate (CR+PR+SD).
2. To evaluate the preliminary effect,such as time to failure(TTF), time to
death(TTD)
;
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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