Gastrointestinal Hemorrhage Clinical Trial
Official title:
Erythromycin Versus Gastric Lavage to Improve Quality of Endoscopic Examination in Patients With Upper Gastrointestinal Bleeding. A Prospective Randomized Trial.
The researchers will investigate whether erythromycin infusion is better than gastric lavage prior to emergency endoscopy to improve the quality of examination in patients with upper gastrointestinal bleeding.
The researchers will investigate whether erythromycin infusion is better than gastric lavage
prior to emergency endoscopy to improve the quality of examination in patients with upper
gastrointestinal bleeding.
One hundred and twenty-two patients admitted within 12 hours after hematemesis will be
randomly assigned to receive erythromycin infusion or gastric lavage by nasogastric tube
prior to emergency endoscopy. The endoscopic procedures will be recorded on Digital Video
Disc (DVD). Two endoscopists blinded to the cleansing strategy will assess the quality of
examination of the upper gastrointestinal tract by using scales designed by Frossard and
Avgerinos .
Secondary endpoints will be the need for a second-look endoscopy, the mean number of blood
units transfused, the need of surgery or arteriography, and the mean duration of
hospitalization
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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