Gastroesophageal Reflux Clinical Trial
Official title:
Phenotypic Characterization of Pediatric Patients With Esophageal Eosinophilia and Biomarkers Investigation for the Diagnosis of Eosinophilic Esophagitis
The purpose of this study is to find out some potential biomarkers for the Eosinophilic Esophagitis (EoE) in pediatric patients through the prospective clinical characterization and assessment of samples collected during the diagnostic process
This study collects clinical information from pediatric patients between 0-18 years old who
have been undergoing upper gastrointestinal endoscopy due to general complaints. The
demographic, clinical symptoms, endoscopy, pH monitoring, and histology data are assessed
during the diagnostic process. In the baseline endoscopy procedure samples (blood, saliva,
esophageal tissue, and esophageal mucus) are taken. After diagnostic process of EoE and
Gastroesophageal reflux disease (GERD) supported by International Guidelines the patients are
divided into three groups - EoE, GERD, and Control.
The techniques are used for patients characterization and assessment:
1. Symptoms score: General symptom score and/or Pediatric Eosinophilic Esophagitis Symptom
Score (PEESS v2.0) - translated and adapted version for Brazilian Portuguese
2. Endoscopic Score: Eosinophilic Esophagitis (EoE) Endoscopic Reference Score (EREFS)
3. Peak eosinophil count (PEC) and histological features description
4. Proteomic analyses
5. Microbiome analyses
6. Immunohistochemistry analyses
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