Gastroesophageal Reflux Clinical Trial
This study investigates the prevalence and pathophysiology of dental and periodontal
involvement in pediatric patients with symptomatic or asymptomatic gastroesophageal reflux
(GER) or gastroesophageal reflux disease (GERD). Primary objectives are to compare the
prevalence of oral disease in children with and without a diagnosis or symptoms/signs of
GERD in a cross-sectional study. Secondary objectives are to examine factors that might lead
to the pathogenesis of the dental and periodontal lesions observed in this group of
subjects.
The primary hypothesis is to prove that children aged 10-18 years diagnosed with or having
symptoms or signs of GERD have a significantly higher amount of dental erosions in
comparison to a matched control group.
Secondary hypotheses are that children aged 10 - 18 years diagnosed with or having signs of
GER have higher DMFS (Decayed, Missing, Filled permanent tooth Surfaces) rates, higher SBI
(Sulcus Bleeding Index) rates, worse Periodontal status, and lower saliva buffering
capacity.
n/a
Observational Model: Case Control, Time Perspective: Cross-Sectional
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