Gastroesophageal Reflux Clinical Trial
Official title:
The Role of Reflux in Innate Immunity Activation After Lung Transplantation.
Recent data has suggested that GER (gastric reflux) may worsen after lung transplantation
and potentially increase the risk of chronic rejection (CR) after lung transplantation.
The purpose of this study is to look at how often GER occurs in the lung transplant
population and examine how GER may change the immune system and cause CR. In this way, we
would be able to better identify patients that may benefit from anti-reflux procedures.
Part of standard pre-transplant work up includes a gastrointestinal (GI) work-up to check
for GER. The following procedures will be done pre-transplant.
1. Standard GER questionnaire (RDQ): This is a 12 item questionnaire. This questionnaire
will ask questions about any reflux symptoms present.
2. Esophagogastroduodenoscopy (EGD): This test will determine evidence of esophageal
reflux and presence of a hiatal hernia.
3. Scintigraphic evaluation of solid gastric emptying: This measures the speed with which
food empties from the stomach and enters the small intestine.
4. Twenty-four hour ambulatory pH testing: The ambulatory 24-hour pH monitoring test will
monitor the acid in the esophagus during a 24-hour period.
5. Esophageal manometry testing: This procedure is done to evaluate the cause of reflux of
stomach acid and contents back into the esophagus, and to determine the cause of
problems with swallowing food.
These procedures will be done again at 3 to 6 months post transplant. The results of the
EGD, scintigraphic evaluation, answers of RDQ, pH testing, esophageal manometry and
bronchoscopy will be collected as well as spirometries and any episodes of rejection.
;
Observational Model: Cohort, Time Perspective: Prospective
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