Gastroesophageal Reflux Clinical Trial
— BEOfficial title:
Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus (Previously: Methylation in Cancer Progression of Barrett's Esophagus
Verified date | May 2024 |
Source | Johns Hopkins University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of this study is to determine if there are any early changes in DNA markers of blood and esophageal tissue in people with gastric reflux, Barrett's esophagus or esophageal cancer that can warn of a progression to esophageal cancer.
Status | Active, not recruiting |
Enrollment | 600 |
Est. completion date | May 1, 2025 |
Est. primary completion date | May 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 95 Years |
Eligibility | Inclusion Criteria: - People who are undergoing upper endoscopy as part of their medical care with a history of esophageal cancer, Barrett's esophagus, or upper gastrointestinal symptoms. Exclusion Criteria: - People who are are currently having chemotherapy, or who have completed chemotherapy within the last 4 weeks. - People who have ever had radiation treatments to their chest. |
Country | Name | City | State |
---|---|---|---|
United States | Johns Hopkins Hospital | Baltimore | Maryland |
Lead Sponsor | Collaborator |
---|---|
Johns Hopkins University | National Cancer Institute (NCI), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | early predictors of esophageal cancer | To see if changes in certain areas of DNA can predict risk for esophageal cancer | 3 |
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