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Continuing Somatostatin Analogues Upon Progression in Neuroendocrine Tumour pAtients — SAUNA  

Gastroenteropancreatic Neuroendocrine Tumor Clinical Trial

Official title:
Continuing Somatostatin Analogues Upon Progression in Neuroendocrine Tumour pAtients - The SAUNA Trial

Clinical Trial Summary

The SAUNA trial is a multi-national, multi-centre, open-label, randomised, controlled, pragmatic clinical trial in patients with advanced, non-functional gastroenteropancreatic (GEP) neuroendocrine tumours (NET) with progressive disease on first-line therapy with somatostatine analogues (SSA). Eligible patients will be divided into two substudies according to the second-line therapy of choice (peptide receptor radionuclide therapy (PRRT) or targeted therapy, at the discretion of the local investigator). Patients within each substudy will be randomised 1:1 between continuation or withdrawal from SSA at the start of second-line systemic therapy. Stratification will occur according to study site and according to the Ki67 value (below 10% (grade 1 and low grade 2) and equal to or above 10% (high grade 2)).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05701241
Study type Interventional
Source University Hospital, Antwerp
Contact Marc U Peeters, MD
Phone 03821
Email sauna@uza.be
Status Recruiting
Phase Phase 4
Start date June 28, 2023
Completion date April 2034
View Details
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