The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping

Gastric Cancer Clinical Trial

Official title:

The Effect of Perioperative Lidocaine Intravenous Infusion on Neutrophil Extracellular Trapping After Surgery for Stomach Cancer

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT04868747
• Other study ID #: NET-lidocaine-stomach cancer
• Status: Withdrawn
• Phase: N/A
• Start date: April 1, 2021
• Est. completion date: April 2, 2021

Study information

• Verified date: January 2023
• Source: The Catholic University of Korea
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To investigate the effect of perioperative lidocaine infusion on the neutrophil extracellular trapping after minimally invasive surgery for stomach cancer

Description:

To investigate the effect of perioperative lidocaine infusion on the neutrophil extracellular trapping, especially citrullinated histone3, neutrophil elastase, myeloperoxidase

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: April 2, 2021
• Est. primary completion date: April 2, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• diagnosis of stomach cancer

• ASA class I-III

• no metastatic disease

Exclusion Criteria:

• hepatic, renal disease

• chronic inflammatory disease, eg. rheumatoid arthritis

• steroid or anti-inflammatory drug medication

• allergies to study drugs

• neuropsychiatric disease

• refusal of participation

• breast feeding or pregnancy

• weight < 40 kg

Related Conditions & MeSH terms

• Gastric Cancer
• Stomach Neoplasms

Intervention

Drug:
• Lidocaine
The participants receive perioperative lidocaine infusion with general anesthesia for gastrectomy.
• normal saline
The participants receive perioperative normal slaine infusion with general anesthesia for gastrectomy.

Locations

Country	Name	City	State
Korea, Republic of	Seoul St.Mary's Hospital	Seoul	Seocho-gu

Sponsors (1)

Lead Sponsor	Collaborator
The Catholic University of Korea

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	serum concentration of NET(neutrophil extracellular trapping)-related biomarker	NET-related biomarker (citrullinated histone3, neutrophil elastase, myeloperoxidase)	24 hours after surgery
Secondary	quality of recovery	The quality of recovery is assessed using questionnaire. This questionnaire includes 15 items. The score range is from 0 to 150. The higher score means the better quality of recovery after surgery.	24 hours after surgery
Secondary	postoperative pain	The postoperative pain is assessed using numeric rating scale (NRS; 0=no pain, 10=the maximal pain)	24 hours after surgery
Secondary	survival of patients	The survival of patients is assessed using electronic medical record.	5 years