Gastric Cancer Clinical Trial
Official title:
Postgenome-based Systemic Discovery of Strong Biomarkers Predict Gastric Cancer Chemotherapy Response
- discovery and validation of biomarker predicting gastric cancer chemotherapy response - Analysis for expression level of mRNA using Next generation sequencing in gastric cancer tissue by chemotherapy response - Analysis for expression level of miRNA using Next generation sequencing in gastric cancer tissue and blood by chemotherapy response - Validation of mRNA and miRNA using qRT-PCR in multiple independent cohort - Biological biomarkers-clinical factor combined prediction model of gastric cancer chemotherapy response
| Status | Recruiting |
| Enrollment | 800 |
| Est. completion date | December 31, 2024 |
| Est. primary completion date | December 31, 2024 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 20 Years to 80 Years |
| Eligibility | Inclusion Criteria: - new gastric cancer patients who has scheduled to start 1st cycle of chemotherapy - patients who agreed this study and voluntarily assigned the informed consents. Exclusion Criteria: - patients who refused the study. - patients who have other cancers - heavy alcoholics |
| Country | Name | City | State |
|---|---|---|---|
| Korea, Republic of | Kyungpook National University Medical Canter | Daegu |
| Lead Sponsor | Collaborator |
|---|---|
| Kyungpook National University Hospital |
Korea, Republic of,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Discovery of predicting bio-markers for gastric cancer chemotherapy response | Discovery of predicting bio-markers for gastric cancer chemotherapy response using next generation sequencing and qRT-PCR | up to 36 months | |
| Secondary | Combination prediction model for adjuvant chemotherapy response in gastric cancer | Combination prediction model of biologic biomarkers and clinical factors for the response of adjuvant chemotherapy in gastric cancer | up to 5 years | |
| Secondary | Combination prediction model for palliative chemotherapy response in gastric cancer | Combination prediction model of biologic biomarkers and clinical factors for the response of palliative chemotherapy in gastric cancer | up to 3 years |
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