Gastric Cancer Clinical Trial
Official title:
The Effect of Glucagon Like Peptide-1 (GLP-1) on Glycaemic Profile and Eating Behaviour Following Gastrectomy
Patients who have undergone gastrectomy (removal of the stomach) to treat or prevent cancer
are known to have a significantly reduced quality of life. To date, there is very little
information on the physiological causes of this. The investigators suspect that
overproduction of a hormone (chemical) called glucagon like peptide-1 (GLP-1) released by the
lining of the gut may play a role in the reduced appetite, weight loss and low blood sugar
symptoms seen in this group. To investigate this, the investigators will study the response
of 16 patients who have previously had a gastrectomy to a glucose drink, and a meal, while
receiving an infusion of a specific blocker of GLP-1 or placebo. The investigators will
examine the levels of sugar and associated hormones in the blood, food consumption and food
reward behaviour using standard tools.
Participants will be invited to attend the Clinical Research Facility at Addenbrooke's
Hospital for a screening visit, and two whole day study visits. The study has been designed
to assess the role of overproduction of GLP-1 by completely blocking its actions, rather than
assess the use of the blocking compound as a medication, and is therefore regarded as a
physiological study, not a clinical trial.
The goal of this study is to demonstrate the magnitude of effect of GLP-1 on blood sugar and
appetite derangement in patients who have had a gastrectomy. This will guide future work on
the development of novel treatment paradigms for the post-gastrectomy patient group.
n/a
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