Gastric Cancer Clinical Trial
Official title:
Phase 1 Study of CEA Specific Cytotoxic T Lymphocytes Induced by Dendritic Cells Infected by Recombinant Adeno-associated Virus With CEA Gene in Stage IV Gastric Cancer
The purpose of this study is to evaluate the clinical safety and preliminary efficacy of CEA specific cytotoxic T lymphocytes induced by dendritic cells infected by recombinant adeno-associated virus with CEA gene in the treatment of stage IV gastric cancer patients.
Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in
cell adhesion.CEA is normally produced in gastrointestinal tissue during fetal development,
but the production stops before birth. The serum levels are raised in some types of
cancer,such as Gastric Cancer.The expression of CEA in these cancers and succedent
unfavourable prognosis such as tumor hyperplasia, recurrence make CEA become the desirable
therapeutic target.
Cancer immunotherapy is the use of the immune system to treat cancer. Immunotherapies fall
into three main groups: cellular, antibody and cytokine.Cellular therapies involve the
removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor
are activated, cultured and returned to the patient where the immune cells attack the
cancer. Cytotoxic T cells and dendritic cells can be used in cell-based immunotherapy.
This study is for patients that have a stage ā…£ gastric cancer with elevated serum CEA
concentration. This research study uses special immune system cells called CEA-specific
cytotoxic T lymphocytes , a new experimental therapy.
Blood will be collected from the patient and the CEA-specific CTLs will be made.The cells
will be injected by IV into the patient.The investigators will follow the patient from their
last infusion,monitor side effects of immunotherapy and learn more about the way the T cells
are working in the patient's body.The investigators will use blood samples to see how long
the T cells last and to look at the immune response to the patient's response to cancer.
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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