Gastric Cancer Clinical Trial
Official title:
Effect of Peritoneal Lavage on Surgery-induced Positive Peritoneal Cytology in Gastric Cancer Patients
Surgical manipulation and handling of a tumor may cause dissemination of cancer cells through peritoneal cavity after curative gastrectomy. Intra operative peritoneal lavage may have preventive effect on positive peritoneal cytology occurred during gastrectomy in patients with gastric cancer.
Peritoneal dissemination of gastric adenocarcinoma cells is the most frequent cause of death
in patients with gastric cancer. Spreading of these cells occur by three routes: direct
seeding via infiltration through gastric wall, via blood vessels and via perigastric
lymphatic channels disturbed during lymph node dissection. Conversion of negative
preoperative peritoneal cytology to positive cytology after curative gastrectomy has been
shown by previous studies.
Although extensive intra-operative peritoneal lavage (1 L of physiologic saline 10 times)
has been shown to be an effective method to eliminate cancer cell dissemination during
surgery, to cause significant improvement in survival after gastrectomy, widespread use of
this approach has not existed most probably due to its time consuming technical difficulty.
Therefore,intra-operative peritoneal lavage (1 L of physiologic saline 3 times) may be used
more frequently during gastric surgery.If it is possible to show effectivity of
intra-operative peritoneal lavage using a total of 3 L physiologic saline to eliminate
cancer cell dissemination occurred before or after gastric surgery, use of this approach may
gain acceptance to decrease risk of peritoneal metastasis.
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Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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