Gastric Cancer Clinical Trial
Official title:
Fast-track Surgery Recovery Program With Early Jejunostomy Nutrition Protocol Minimizes Time to Adjuvant Chemotherapy in Patients Undergoing Laparoscopic Gastrectomy for Gastric Cancer
Adjuvant chemotherapy (AC) for gastric cancer is known to improve prognosis, and longer time
to AC is associated with worse survival. However, most clinical trials mandate that AC is
still to commence within 6 to 8 weeks after surgery consideration for malnutrition,
postoperative complications and intolerance of AC. Placement of jejunostomy nutrition tube
for enteral nutrition is a common component of these procedures, as a result of superior
postoperative organ function, decreased infection rates, and a greater likelihood to
complete AC with enteral nutritional support.
Fast-track surgery (FTS) recovery program focuses on enhancing recovery and reducing
morbidity. Introduction of FTS concepts are safe, feasible, and can achieve shorter hospital
stays and reduced costs. Early postoperative enteral nutrition combined with FTS results in
reductions in total complications compared with traditional postoperative feeding practices
and does not negatively affect outcomes. However, the benefit of jejunostomy nutrition tube
routine placement and combination with FTS is still being debated. Besides, there remains
some controversy over the optimal combination of nutrients and duration and timing and
routes of feed administration.
The aim of this study was to determine whether FTS with early jejunostomy nutrition (EJN)
following laparoscopic gastrectomy for gastric cancer improved postoperative recovery and
minimizes time to AC when compared with FTS with early oral nutrition (EON).
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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